Richardson C T
Am J Med. 1985 Aug 30;79(2C):1-7. doi: 10.1016/0002-9343(85)90564-9.
Peptic ulcers are believed to develop because of increased acid and pepsin secretion, a reduced mucosal defense mechanism, or a combination of these two abnormalities. Environmental factors such as use of nonsteroidal and steroidal anti-inflammatory drugs, smoking, and emotional stress may play a role in the pathogenesis of ulcer disease in some patients. The exact mechanisms whereby these factors cause ulcers is unknown, although it is likely that non-steroidal drugs cause ulcers by reducing mucosal defense mechanisms whereas emotional stress may lead to ulceration by increasing acid secretion and/or decreasing mucosal defense mechanisms. Genetic factors may be important in the pathogenesis of ulcers in some patients.
消化性溃疡被认为是由于胃酸和胃蛋白酶分泌增加、黏膜防御机制减弱或这两种异常情况共同作用而形成的。环境因素，如使用非甾体和甾体类抗炎药、吸烟以及情绪压力，在某些患者的溃疡病发病机制中可能起作用。尽管非甾体类药物可能通过降低黏膜防御机制导致溃疡，而情绪压力可能通过增加胃酸分泌和/或降低黏膜防御机制导致溃疡形成，但这些因素导致溃疡的确切机制尚不清楚。遗传因素在某些患者的溃疡发病机制中可能很重要。
