Sanders A B, Ewy G A, Bragg S, Atlas M, Kern K B
Ann Emerg Med. 1985 Oct;14(10):948-52. doi: 10.1016/s0196-0644(85)80235-3.
We performed a study to determine if the measurement of expired PCO2 during CPR for cardiac arrest could be used as a prognostic indicator of successful resuscitation. Twelve mongrel dogs were fibrillated electrically, and external chest massage and assisted ventilation were applied for 15 minutes. Expired PCO2 and aortic and right atrial pressures were monitored each minute of arrest. Coronary perfusion pressure (CPP) was calculated by subtracting the right atrial from the aortic diastolic pressure. Half the dogs received high-force chest compression (80 lb) and half received low-force chest compression (40 lb). The six dogs that received high-force compression were resuscitated successfully. The expired PCO2 was significantly higher in the successfully resuscitated dogs (expired PCO2 = 9.6 +/- 3.2 mm Hg) when compared to those dogs that died (expired PCO2 = 3.2 +/- 1.1 mm Hg, P less than .01). Expired PCO2 was highly correlated (r = 0.91, P less than .01) with the CPPs. The measurement of expired PCO2 during attempted CPR may be useful as a noninvasive indicator of CPP and adequate technique. Further studies on the use of this technique as an assessment criterion are warranted.
我们进行了一项研究，以确定在心脏骤停心肺复苏期间测量呼出二氧化碳分压（PCO2）是否可作为成功复苏的预后指标。将12只杂种狗进行电致颤，并进行15分钟的体外胸外按压和辅助通气。在心脏骤停的每分钟监测呼出PCO2、主动脉压和右心房压。冠状动脉灌注压（CPP）通过主动脉舒张压减去右心房压来计算。一半的狗接受高强度胸外按压（80磅），另一半接受低强度胸外按压（40磅）。接受高强度按压的6只狗成功复苏。与死亡的狗相比，成功复苏的狗呼出PCO2显著更高（呼出PCO2 = 9.6±3.2毫米汞柱）（死亡狗呼出PCO2 = 3.2±1.1毫米汞柱，P＜0.01）。呼出PCO2与CPP高度相关（r = 0.91，P＜0.01）。在尝试进行心肺复苏期间测量呼出PCO2可能作为CPP和适当技术的无创指标有用。对将该技术用作评估标准进行进一步研究是必要的。
