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微生物简介:适用于每个生态位的抗生素。

Microbe Profile: : antibiotics for every niche.

机构信息

Department of Molecular Microbiology, John Innes Centre, Norwich Research Park, Norwich, NR4 7UH, UK.

Instituto de Investigaciones Farmacéuticas (INIFAR) and Centro de Investigaciones en Productos Naturales (CIPRONA), Universidad de Costa Rica, San José 11501-2060, Costa Rica.

出版信息

Microbiology (Reading). 2024 Sep;170(9). doi: 10.1099/mic.0.001501.

Abstract

species comprise a genus of filamentous, sporulating bacteria belonging to the phylum Actinomycetota, formerly Actinobacteria. They are found in marine and freshwater sediments and soils and associated with marine animals, insects, and plants. To date, they have mostly been studied because of their mutually beneficial symbiosis with fungus-growing ants in the tribe . They have also attracted interest due to their biosynthetic capabilities, including the production of variably glycosylated polyenes and other novel antifungal compounds, and for their capacity to grow on a variety of hydrocarbons. The majority of clinically used antibiotics are derived from the specialised metabolites of filamentous actinomycete bacteria and most of these come from the genus . However, in the quest for novel chemistry there is increasing interest in studying other filamentous actinomycete genera, including . Here we outline the biological properties, genome size and structure and key features of the genus , namely their specialised metabolites and ecological roles.

摘要

种构成了丝状、孢子形成的细菌属,属于放线菌门,以前称为放线菌门。它们存在于海洋和淡水沉积物和土壤中,并与海洋动物、昆虫和植物有关。迄今为止,它们主要因其与真菌生长蚂蚁的互利共生而受到研究,在 部落中。由于它们的生物合成能力,包括产生变糖基多烯和其他新型抗真菌化合物,以及它们能够在各种碳氢化合物上生长,它们也引起了人们的兴趣。大多数临床使用的抗生素都来自丝状放线菌细菌的特殊代谢物,其中大多数来自属。然而,在寻求新的化学物质的过程中,人们越来越有兴趣研究其他丝状放线菌属,包括 。在这里,我们概述了该属的生物学特性、基因组大小和结构以及主要特征,即它们的特殊代谢物和生态作用。

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