• 文献检索
  • 文档翻译
  • 深度研究
  • 学术资讯
  • Suppr Zotero 插件Zotero 插件
  • 邀请有礼
  • 套餐&价格
  • 历史记录
应用&插件
Suppr Zotero 插件Zotero 插件浏览器插件Mac 客户端Windows 客户端微信小程序
定价
高级版会员购买积分包购买API积分包
服务
文献检索文档翻译深度研究API 文档MCP 服务
关于我们
关于 Suppr公司介绍联系我们用户协议隐私条款
关注我们

Suppr 超能文献

核心技术专利：CN118964589B侵权必究
粤ICP备2023148730 号-1Suppr @ 2026

文献检索

告别复杂PubMed语法，用中文像聊天一样搜索，搜遍4000万医学文献。AI智能推荐，让科研检索更轻松。

立即免费搜索

文件翻译

保留排版，准确专业，支持PDF/Word/PPT等文件格式，支持 12+语言互译。

免费翻译文档

深度研究

AI帮你快速写综述，25分钟生成高质量综述，智能提取关键信息，辅助科研写作。

立即免费体验

山葵中异硫氰酸酯（）-6-HITC在脂多糖诱导的炎症小鼠模型中的免疫调节作用及调控机制

Immunomodulatory Effects and Regulatory Mechanisms of ()-6-HITC, an Isothiocyanate from Wasabi (), in an Mouse Model of LPS-Induced Inflammation.

作者信息

Alcarranza Manuel, Alarcón-de-la-Lastra Catalina, Recio Jiménez Rocío, Fernández Inmaculada, Castejón Martínez María Luisa, Villegas Isabel

机构信息

Instituto de Biomedicina de Sevilla, IBiS/Hospital Universitario Virgen del Rocío/CSIC/Universidad de Sevilla, 41013 Sevilla, Spain.

Departamento de Farmacología, Facultad de Farmacia, Universidad de Sevilla, 41012 Sevilla, Spain.

出版信息

J Agric Food Chem. 2024 Oct 2;72(39):21520-21532. doi: 10.1021/acs.jafc.4c02943. Epub 2024 Sep 19.

DOI:10.1021/acs.jafc.4c02943
PMID:39298284
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC11450934/
Abstract

The present study aimed to investigate the effects of ()-(-)-1-isothiocyanato-6-(methylsulfinyl)-hexane [()-6-HITC], the major isothiocyanate present in wasabi, in an model of inflammation using lipopolysaccharide-stimulated murine peritoneal macrophages. ()-6-HITC improved the immune response and mitigated oxidative stress, which involved suppression of reactive oxygen species, nitric oxide, and pro-inflammatory cytokines (IL-1β, IL-6, IL-17, IL-18, and TNF-α) production and downregulation of pro-inflammatory enzymes such as inducible nitric oxide synthase, COX-2, and mPGES-1. In addition, ()-6-HITC was able to activate the Nrf2/HO-1 axis while simultaneously inhibiting key signaling pathways, including JAK2/STAT3, mitogen-activated protein kinases, and canonical and noncanonical inflammasome pathways, orchestrating its potent immunomodulatory effects. Collectively, these findings demonstrate the potential of ()-6-HITC as a promising nutraceutical for the management of immuno-inflammatory diseases and justify the need for further validation studies.

摘要

本研究旨在利用脂多糖刺激的小鼠腹腔巨噬细胞炎症模型，研究山葵中主要异硫氰酸酯（）-（-）-1-异硫氰酸酯-6-（甲基亚磺酰基）己烷[（）-6-HITC]的作用。（）-6-HITC改善了免疫反应并减轻了氧化应激，这涉及抑制活性氧、一氧化氮和促炎细胞因子（IL-1β、IL-6、IL-17、IL-18和TNF-α）的产生，并下调诱导型一氧化氮合酶、COX-2和mPGES-1等促炎酶。此外，（）-6-HITC能够激活Nrf2/HO-1轴，同时抑制关键信号通路，包括JAK2/STAT3、丝裂原活化蛋白激酶以及经典和非经典炎性小体通路，从而发挥其强大的免疫调节作用。总的来说，这些发现证明了（）-6-HITC作为一种有前途的营养保健品用于管理免疫炎症性疾病的潜力，并证明有必要进行进一步的验证研究。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/31fc/11450934/25614ecb046b/jf4c02943_0008.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/31fc/11450934/f366b606788b/jf4c02943_0009.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/31fc/11450934/5da44183fc92/jf4c02943_0001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/31fc/11450934/46871c051cb4/jf4c02943_0002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/31fc/11450934/1aa87969e413/jf4c02943_0003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/31fc/11450934/1d7f7941959e/jf4c02943_0004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/31fc/11450934/61c12690c5fa/jf4c02943_0005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/31fc/11450934/e1b8361da120/jf4c02943_0006.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/31fc/11450934/19ec2245d3ce/jf4c02943_0007.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/31fc/11450934/25614ecb046b/jf4c02943_0008.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/31fc/11450934/f366b606788b/jf4c02943_0009.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/31fc/11450934/5da44183fc92/jf4c02943_0001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/31fc/11450934/46871c051cb4/jf4c02943_0002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/31fc/11450934/1aa87969e413/jf4c02943_0003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/31fc/11450934/1d7f7941959e/jf4c02943_0004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/31fc/11450934/61c12690c5fa/jf4c02943_0005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/31fc/11450934/e1b8361da120/jf4c02943_0006.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/31fc/11450934/19ec2245d3ce/jf4c02943_0007.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/31fc/11450934/25614ecb046b/jf4c02943_0008.jpg

相似文献

1
Immunomodulatory Effects and Regulatory Mechanisms of ()-6-HITC, an Isothiocyanate from Wasabi (), in an Mouse Model of LPS-Induced Inflammation.山葵中异硫氰酸酯（）-6-HITC在脂多糖诱导的炎症小鼠模型中的免疫调节作用及调控机制
J Agric Food Chem. 2024 Oct 2;72(39):21520-21532. doi: 10.1021/acs.jafc.4c02943. Epub 2024 Sep 19.
2
Ligstroside aglycon, an extra virgin olive oil secoiridoid, prevents inflammation by regulation of MAPKs, JAK/STAT, NF-κB, Nrf2/HO-1, and NLRP3 inflammasome signaling pathways in LPS-stimulated murine peritoneal macrophages.橄榄苦苷配基，特级初榨橄榄油中的一种次生物，通过调节 LPS 刺激的鼠腹腔巨噬细胞中的 MAPKs、JAK/STAT、NF-κB、Nrf2/HO-1 和 NLRP3 炎性小体信号通路来预防炎症。
Food Funct. 2022 Oct 3;13(19):10200-10209. doi: 10.1039/d2fo00351a.
3
Peracetylated hydroxytyrosol, a new hydroxytyrosol derivate, attenuates LPS-induced inflammatory response in murine peritoneal macrophages via regulation of non-canonical inflammasome, Nrf2/HO1 and JAK/STAT signaling pathways.过乙酰化羟基酪醇，一种新的羟基酪醇衍生物，通过调节非经典炎性小体、Nrf2/HO1 和 JAK/STAT 信号通路，减轻 LPS 诱导的小鼠腹腔巨噬细胞炎症反应。
J Nutr Biochem. 2018 Jul;57:110-120. doi: 10.1016/j.jnutbio.2018.03.014. Epub 2018 Mar 18.
4
Role of Nrf2 in suppressing LPS-induced inflammation in mouse peritoneal macrophages by polyunsaturated fatty acids docosahexaenoic acid and eicosapentaenoic acid.Nrf2 在多不饱和脂肪酸二十二碳六烯酸和二十碳五烯酸抑制脂多糖诱导的小鼠腹腔巨噬细胞炎症中的作用。
Mol Pharm. 2010 Dec 6;7(6):2185-93. doi: 10.1021/mp100199m. Epub 2010 Oct 6.
5
Anti-inflammatory effects of a traditional Korean medicine: Ojayeonjonghwan.一种传统韩药——五叶延胡索丸的抗炎作用
Pharm Biol. 2017 Dec;55(1):1856-1862. doi: 10.1080/13880209.2017.1339282.
6
The Anti-Inflammatory Effect of C. DC. in the Lipopolysaccharide-Stimulated Inflammatory Response in Macrophages and Airway Epithelial Cells and in LPS-Challenged Mice.C. DC. 在脂多糖刺激的巨噬细胞和气道上皮细胞炎症反应及脂多糖 challenged 小鼠中的抗炎作用。
J Microbiol Biotechnol. 2020 Nov 28;30(11):1614-1625. doi: 10.4014/jmb.2006.06042.
7
Geniposide suppresses LPS-induced nitric oxide, PGE2 and inflammatory cytokine by downregulating NF-κB, MAPK and AP-1 signaling pathways in macrophages.京尼平苷通过下调巨噬细胞中的NF-κB、MAPK和AP-1信号通路来抑制脂多糖诱导的一氧化氮、前列腺素E2和炎性细胞因子。
Int Immunopharmacol. 2014 Jun;20(2):298-306. doi: 10.1016/j.intimp.2014.04.004. Epub 2014 Apr 13.
8
Extra virgin olive oil polyphenolic extracts downregulate inflammatory responses in LPS-activated murine peritoneal macrophages suppressing NFκB and MAPK signalling pathways.特级初榨橄榄油多酚提取物可下调脂多糖激活的小鼠腹腔巨噬细胞中的炎症反应，抑制核因子κB和丝裂原活化蛋白激酶信号通路。
Food Funct. 2014 Jun;5(6):1270-7. doi: 10.1039/c4fo00014e. Epub 2014 Apr 17.
9
Ethyl acetate fraction from Nymphaea hybrida Peck modulates inflammatory responses in LPS-stimulated RAW 264.7 cells and acute inflammation murine models.芡荷叶乙酸乙酯部位对脂多糖诱导的 RAW264.7 细胞炎症反应和急性炎症模型的调节作用。
J Ethnopharmacol. 2021 Apr 6;269:113698. doi: 10.1016/j.jep.2020.113698. Epub 2020 Dec 15.
10
Inhibitory Effects of Decne. Extract on Inflammatory and Oxidative Responses in LPS-Treated Macrophages.丹皮酚提取物对 LPS 处理的巨噬细胞炎症和氧化反应的抑制作用。
Molecules. 2020 Mar 15;25(6):1336. doi: 10.3390/molecules25061336.

本文引用的文献

1
5-methylthiopentyl Isothiocyanate, a Sulforaphane Analogue, Inhibits Pro-inflammatory Cytokines by Regulating LPS/ATP-mediated NLRP3 Inflammasome Activation.5-甲基巯基戊基异硫氰酸酯，一种莱菔硫烷类似物，通过调节 LPS/ATP 介导的 NLRP3 炎性体激活来抑制促炎细胞因子。
Curr Pharm Biotechnol. 2024;25(5):645-654. doi: 10.2174/1389201024666230824093927.
2
()-8-Methylsulfinyloctyl isothiocyanate from inhibits LPS-induced immunoinflammatory responses in mouse peritoneal macrophages: chemical synthesis and molecular signaling pathways involved.来自[具体来源未明确]的（）-8-甲基亚磺酰辛基异硫氰酸酯抑制小鼠腹腔巨噬细胞中脂多糖诱导的免疫炎症反应：化学合成及相关分子信号通路
Food Funct. 2023 Jul 31;14(15):7270-7283. doi: 10.1039/d3fo02009f.
3
Allyl isothiocyanate inhibits cell migration and invasion in human gastric cancer AGS cells via affecting PI3K/AKT and MAPK signaling pathway in vitro.
丙烯基异硫氰酸酯通过体外影响 PI3K/AKT 和 MAPK 信号通路抑制人胃癌 AGS 细胞的迁移和侵袭。
Environ Toxicol. 2023 Oct;38(10):2287-2297. doi: 10.1002/tox.23864. Epub 2023 Jun 15.
4
Chemical composition of extracts from leaves, stems and roots of wasabi (Eutrema japonicum) and their anti-cancer, anti-inflammatory and anti-microbial activities.山葵（山萮菜）叶、茎和根提取物的化学成分及其抗癌、抗炎和抗菌活性。
Sci Rep. 2023 Jun 5;13(1):9142. doi: 10.1038/s41598-023-36402-y.
5
Benzyl isothiocyanate attenuates activation of the NLRP3 inflammasome in Kupffer cells and improves diet-induced steatohepatitis.异硫氰酸苄酯可减轻库普弗细胞中NLRP3炎性小体的激活，并改善饮食诱导的脂肪性肝炎。
Toxicol Appl Pharmacol. 2023 Mar 1;462:116424. doi: 10.1016/j.taap.2023.116424. Epub 2023 Feb 10.
6
Anti-tumor effect of Wasabi component, 6-(methylsulfinyl) hexyl isothiocyanate, against endometrial carcinoma cells.芥末成分6-（甲基亚磺酰基）己基异硫氰酸酯对子宫内膜癌细胞的抗肿瘤作用。
Discov Oncol. 2023 Jan 23;14(1):9. doi: 10.1007/s12672-023-00617-2.
7
Clinical effects of wasabi extract containing 6-MSITC on myalgic encephalomyelitis/chronic fatigue syndrome: an open-label trial.含6-甲磺酰基异硫氰酸酯的山葵提取物对肌痛性脑脊髓炎/慢性疲劳综合征的临床疗效：一项开放标签试验。
Biopsychosoc Med. 2022 Dec 12;16(1):26. doi: 10.1186/s13030-022-00255-0.
8
Variation in the main health-promoting compounds and antioxidant activity of different organs of Wasabi (Eutrema ) from two producing areas.来自两个产地的山葵（辣根属）不同器官中主要健康促进化合物和抗氧化活性的差异。
Front Plant Sci. 2022 Oct 26;13:1043378. doi: 10.3389/fpls.2022.1043378. eCollection 2022.
9
Wasabi () Reduces Obesity and Blood Pressure in Diet-Induced Metabolic Syndrome in Rats.山葵（）可减轻饮食诱导的大鼠代谢综合征中的肥胖和血压。
Foods. 2022 Oct 29;11(21):3435. doi: 10.3390/foods11213435.
10
Ligstroside aglycon, an extra virgin olive oil secoiridoid, prevents inflammation by regulation of MAPKs, JAK/STAT, NF-κB, Nrf2/HO-1, and NLRP3 inflammasome signaling pathways in LPS-stimulated murine peritoneal macrophages.橄榄苦苷配基，特级初榨橄榄油中的一种次生物，通过调节 LPS 刺激的鼠腹腔巨噬细胞中的 MAPKs、JAK/STAT、NF-κB、Nrf2/HO-1 和 NLRP3 炎性小体信号通路来预防炎症。
Food Funct. 2022 Oct 3;13(19):10200-10209. doi: 10.1039/d2fo00351a.