Chen Zizhao, Feng Pingping, Wang Ruqi, Chen Dongmin, Feng Chunmei, Jin Qishu, Yang Chen, Song Botao
Joint Centre of Translational Medicine, the First Affiliated Hospital of Wenzhou Medical University, Wenzhou 325000, China; Key Laboratory of Synthetic and Natural Functional Molecule of the Ministry of Education, College of Chemistry and Materials Science, Northwest University, Xi'an, Shaanxi 710069, China.
Zhejiang Engineering Research Center for Tissue Repair Materials, Wenzhou Institute, University of Chinese Academy of Sciences, Wenzhou, Zhejiang 325000, China; School of Pharmacy, Zhejiang Chinese Medicine University, Hangzhou 310053, China.
Colloids Surf B Biointerfaces. 2025 Jan;245:114246. doi: 10.1016/j.colsurfb.2024.114246. Epub 2024 Sep 15.
The use of dressings in clinical settings is common for the purpose of wound wrapping and creating an optimal microenvironment to enhance the healing process. Proper coverage of wounds with dressings serves as the fundamental basis for effective wound healing. Unfortunately, non-standard coverage by hands can cause pain and secondary damage to patients, while slow manual application during treatment of extensive burns may increase the risk of wound infection. Herein, drawing inspiration from the microstructure and hygroscopic deformation observed in pine cones, we propose a polyvinyl alcohol/polysulfone (PVA/PSF) smart dressing. This bioinspired smart dressing exhibits rapid bending deformation under high moisture condition, allowing easy adjustment of bending amplitude, speed, and direction. Moreover, the smart dressing is capable of rapid bending and autonomous wrapping around "artificial wounds" on a doll's body, as well as fitting irregularly shaped "hand wounds" and extensive "arm wounds" on human subjects. By integrating two layers into one dressing design, we endow it with dual functionality: The hygroscopic PVA layer facilitates transversal liquid transport to effectively reduce exudate accumulation in the wound bed while maintaining proper moisture levels; meanwhile, the highly hydrophobic PSF layer repels various aqueous solutions to protect against external contaminants. In vivo results confirm that this multifunctional smart dressing promotes collagen synthesis and accelerates angiogenesis for accelerated wound healing. We believe that this innovative multifunctional approach to wound management will provide valuable insights into wound healing therapy.
在临床环境中使用敷料来包裹伤口并创造最佳微环境以促进愈合过程是很常见的。用敷料正确覆盖伤口是有效伤口愈合的基本基础。不幸的是，手动非标准覆盖会给患者带来疼痛和二次损伤，而在大面积烧伤治疗过程中手动涂抹缓慢可能会增加伤口感染的风险。在此，从松果中观察到的微观结构和吸湿变形获得灵感，我们提出了一种聚乙烯醇/聚砜（PVA/PSF）智能敷料。这种受生物启发的智能敷料在高湿度条件下表现出快速弯曲变形，能够轻松调节弯曲幅度、速度和方向。此外，该智能敷料能够快速弯曲并自动包裹在玩偶身体上的“人工伤口”周围，还能贴合人体受试者不规则形状的“手部伤口”和大面积的“手臂伤口”。通过将两层整合到一种敷料设计中，我们赋予其双重功能：吸湿的PVA层有助于横向液体传输，有效减少伤口床中的渗出液积聚，同时保持适当的湿度水平；与此同时，高度疏水的PSF层排斥各种水溶液，防止外部污染物侵入。体内实验结果证实，这种多功能智能敷料促进胶原蛋白合成并加速血管生成，从而加速伤口愈合。我们相信，这种创新的多功能伤口管理方法将为伤口愈合治疗提供有价值的见解。
