基于花菁平台的双响应比率型近红外荧光探针用于 Cu 检测及其在体内外的成像。
A dual-response ratiometric near-infrared fluorescence probe based on cyanine platform for Cu detection and its imaging in vitro and vivo.
机构信息
School of Chemistry and Chemical Engineering, Nanjing University of Science and Technology, Nanjing 210094, PR China.
State Key Laboratory of Coordination Chemistry, School of Chemistry and Chemical Engineering, Nanjing University, Nanjing 210093, PR China.
出版信息
Spectrochim Acta A Mol Biomol Spectrosc. 2025 Jan 15;325:125115. doi: 10.1016/j.saa.2024.125115. Epub 2024 Sep 15.
A near-infrared fluorescent probe (NUST-Cy-1) was disclosed here, which displays ratiometric and dual-channel response for Cu (λ = 450 nm, λ = 750 nm) with large Stokes shifts (143 nm, 375 nm, 75 nm respectively). This probe demonstrates high sensitivity with low detection limit (1.4 μM) and selectivity for Cu detection. Furthermore, fluorescent imaging of Cu in vitro and vivo were successfully achieved.
一种近红外荧光探针（NUST-Cy-1）被揭示出来，它对 Cu（λ=450nm，λ=750nm）显示出比率和双通道响应，具有较大的斯托克斯位移（分别为 143nm、375nm、75nm）。该探针对 Cu 的检测具有高灵敏度和低检测限（1.4μM），并且具有选择性。此外，还成功地实现了 Cu 的体外和体内荧光成像。
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