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SETD2 in cancer: functions, molecular mechanisms, and therapeutic regimens.

作者信息

Weng Yawen, Xue Jing, Niu Ningning

机构信息

State Key Laboratory of Systems Medicine for Cancer, Stem Cell Research Center, Ren Ji Hospital, Shanghai Cancer Institute, Shanghai Jiao Tong University School of Medicine, Shanghai 200127, China.

出版信息

Cancer Biol Med. 2024 Sep 19;21(9):725-30. doi: 10.20892/j.issn.2095-3941.2024.0201.

DOI:10.20892/j.issn.2095-3941.2024.0201
PMID:39302028
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC11414219/
Abstract
摘要
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/78da/11414219/7e055466b193/cbm-21-725-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/78da/11414219/05bdc39e874c/cbm-21-725-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/78da/11414219/7e055466b193/cbm-21-725-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/78da/11414219/05bdc39e874c/cbm-21-725-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/78da/11414219/7e055466b193/cbm-21-725-g002.jpg

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SETD2 in cancer: functions, molecular mechanisms, and therapeutic regimens.癌症中的SETD2:功能、分子机制及治疗方案
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2
Structure and function of the lysine methyltransferase SETD2 in cancer: From histones to cytoskeleton.赖氨酸甲基转移酶SETD2在癌症中的结构与功能:从组蛋白到细胞骨架
Neoplasia. 2025 Jan;59:101090. doi: 10.1016/j.neo.2024.101090. Epub 2024 Nov 25.
3
SETting the Stage for Cancer Development: SETD2 and the Consequences of Lost Methylation.为癌症发展搭建舞台:SETD2与甲基化缺失的后果
Cold Spring Harb Perspect Med. 2017 May 1;7(5):a026468. doi: 10.1101/cshperspect.a026468.
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A New Chromatin-Cytoskeleton Link in Cancer.癌症中一种新的染色质-细胞骨架联系
Mol Cancer Res. 2016 Dec;14(12):1173-1175. doi: 10.1158/1541-7786.MCR-16-0250. Epub 2016 Aug 15.
5
The Benzene Hematotoxic and Reactive Metabolite 1,4-Benzoquinone Impairs the Activity of the Histone Methyltransferase SET Domain Containing 2 (SETD2) and Causes Aberrant Histone H3 Lysine 36 Trimethylation (H3K36me3).苯的血液毒性和反应代谢产物 1,4-苯醌会损害组蛋白甲基转移酶 SET 结构域包含 2 蛋白(SETD2)的活性,并导致组蛋白 H3 赖氨酸 36 三甲基化(H3K36me3)异常。
Mol Pharmacol. 2021 Sep;100(3):283-294. doi: 10.1124/molpharm.121.000303. Epub 2021 Jul 15.
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SETD2 as a regulator of N6-methyladenosine RNA methylation and modifiers in cancer.SETD2 作为 N6-甲基腺苷 RNA 甲基化的调节剂和癌症中的修饰物。
Eur J Cancer Prev. 2020 Nov;29(6):556-564. doi: 10.1097/CEJ.0000000000000587.
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SETD2: an epigenetic modifier with tumor suppressor functionality.SETD2:一种具有肿瘤抑制功能的表观遗传修饰因子。
Oncotarget. 2016 Aug 2;7(31):50719-50734. doi: 10.18632/oncotarget.9368.
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SETD2, an epigenetic tumor suppressor: a focused review on GI tumor.SETD2,一种表观遗传肿瘤抑制因子:重点综述胃肠道肿瘤。
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Structure/Function Analysis of Recurrent Mutations in SETD2 Protein Reveals a Critical and Conserved Role for a SET Domain Residue in Maintaining Protein Stability and Histone H3 Lys-36 Trimethylation.SETD2蛋白中复发性突变的结构/功能分析揭示了SET结构域残基在维持蛋白质稳定性和组蛋白H3赖氨酸-36三甲基化方面的关键且保守的作用。
J Biol Chem. 2016 Sep 30;291(40):21283-21295. doi: 10.1074/jbc.M116.739375. Epub 2016 Aug 15.
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Kidney cancer: SETD2 affects DNA replication.肾癌:SETD2影响DNA复制。
Nat Rev Urol. 2015 Apr;12(4):183. doi: 10.1038/nrurol.2015.53. Epub 2015 Mar 17.

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Proteome-wide assessment of differential missense variant clustering in neurodevelopmental disorders and cancer.

本文引用的文献

1
Tumor cell-intrinsic epigenetic dysregulation shapes cancer-associated fibroblasts heterogeneity to metabolically support pancreatic cancer.肿瘤细胞内在的表观遗传失调塑造了与癌症相关的成纤维细胞的异质性,以代谢方式支持胰腺癌。
Cancer Cell. 2024 May 13;42(5):869-884.e9. doi: 10.1016/j.ccell.2024.03.005. Epub 2024 Apr 4.
2
Tumor cell-intrinsic SETD2 inactivation sensitizes cancer cells to immune checkpoint blockade through the NR2F1-STAT1 pathway.肿瘤细胞内在的 SETD2 失活通过 NR2F1-STAT1 通路使癌细胞对免疫检查点阻断敏感。
J Immunother Cancer. 2023 Dec 6;11(12):e007678. doi: 10.1136/jitc-2023-007678.
3
SETD2 deficiency accelerates sphingomyelin accumulation and promotes the development of renal cancer.
神经发育障碍和癌症中错义变异差异聚类的全蛋白质组评估
Cell Genom. 2025 Apr 9;5(4):100807. doi: 10.1016/j.xgen.2025.100807. Epub 2025 Mar 11.
4
Signatures of H3K4me3 modification predict cancer immunotherapy response and identify a new immune checkpoint-SLAMF9.H3K4me3修饰特征可预测癌症免疫治疗反应并鉴定出一种新的免疫检查点——信号淋巴细胞激活分子家族成员9(SLAMF9)。
Respir Res. 2025 Jan 15;26(1):17. doi: 10.1186/s12931-024-03093-6.
SETD2 缺乏加速鞘磷脂积累并促进肾癌的发展。
Nat Commun. 2023 Nov 21;14(1):7572. doi: 10.1038/s41467-023-43378-w.
4
Loss of SETD2 aggravates colorectal cancer progression caused by SMAD4 deletion through the RAS/ERK signalling pathway.SETD2 的缺失会通过 RAS/ERK 信号通路加重 SMAD4 缺失引起的结直肠癌进展。
Clin Transl Med. 2023 Nov;13(11):e1475. doi: 10.1002/ctm2.1475.
5
SETD2 Deficiency Confers Sensitivity to Dual Inhibition of DNA Methylation and PARP in Kidney Cancer.SETD2 缺失赋予肾癌对 DNA 甲基化和 PARP 双重抑制的敏感性。
Cancer Res. 2023 Nov 15;83(22):3813-3826. doi: 10.1158/0008-5472.CAN-23-0401.
6
SETD2 Loss and ATR Inhibition Synergize to Promote cGAS Signaling and Immunotherapy Response in Renal Cell Carcinoma.SETD2 缺失与 ATR 抑制协同作用促进肾细胞癌的 cGAS 信号转导和免疫治疗反应。
Clin Cancer Res. 2023 Oct 2;29(19):4002-4015. doi: 10.1158/1078-0432.CCR-23-1003.
7
SETD2 loss in renal epithelial cells drives epithelial-to-mesenchymal transition in a TGF-β-independent manner.SETD2 缺失在肾上皮细胞中驱动上皮-间充质转化,而不依赖于 TGF-β。
Mol Oncol. 2024 Jan;18(1):44-61. doi: 10.1002/1878-0261.13487. Epub 2023 Jul 17.
8
Tumor Cell-Intrinsic SETD2 Deficiency Reprograms Neutrophils to Foster Immune Escape in Pancreatic Tumorigenesis.肿瘤细胞内在的 SETD2 缺陷重编程中性粒细胞促进胰腺肿瘤发生中的免疫逃逸。
Adv Sci (Weinh). 2023 Jan;10(2):e2202937. doi: 10.1002/advs.202202937. Epub 2022 Dec 1.
9
Glycolysis addiction compensating for a defective pentose phosphate pathway confers gemcitabine sensitivity in SETD2-deficient pancreatic cancer.糖酵解成瘾代偿缺陷的戊糖磷酸途径赋予 SETD2 缺陷型胰腺癌细胞对吉西他滨的敏感性。
Biochem Biophys Res Commun. 2022 Jul 30;615:9-16. doi: 10.1016/j.bbrc.2022.05.047. Epub 2022 May 16.
10
The histone methyltransferase SETD2 modulates oxidative stress to attenuate experimental colitis.组蛋白甲基转移酶SETD2调节氧化应激以减轻实验性结肠炎。
Redox Biol. 2021 Jul;43:102004. doi: 10.1016/j.redox.2021.102004. Epub 2021 May 13.