1 型糖尿病患儿发病时的糖尿病家族史和临床特征：一项瑞典基于人群的研究。
Family History of Diabetes and Clinical Characteristics in Children at Diagnosis of Type 1 Diabetes-A Swedish Population-Based Study.
机构信息
Department of Clinical Sciences Lund, Lund University, Lund, Sweden.
Department of Paediatrics, Kristianstad Central Hospital, Kristianstad, Sweden.
出版信息
Diabetes Care. 2024 Nov 1;47(11):2012-2016. doi: 10.2337/dc24-0534.
OBJECTIVE
To compare the prevalence of parental diabetes between children with and without type 1 diabetes (T1D), and to compare clinical characteristics at diagnosis of T1D in children with, versus without, a family history of diabetes.
RESEARCH DESIGN AND METHODS
Parental diabetes among children with T1D was compared with a general population cohort. Clinical characteristics were compared by family history of diabetes in parents and grandparents of 3,603 children with T1D using relative risk (RR) and ANOVA.
RESULTS
Children with T1D more often had parents with type 2 diabetes (T2D) (RR 1.88; P < 0.001) than did children without diabetes. Children with T1D and a family history of T2D were more likely to be overweight or obese (P = 0.002).
CONCLUSIONS
A family history of T2D and being overweight may contribute to increased risk of T1D.
目的
比较 1 型糖尿病（T1D）患儿与非 T1D 患儿的父母糖尿病患病率，并比较有和无糖尿病家族史的 T1D 患儿的诊断时临床特征。
研究设计和方法
将 T1D 患儿的父母糖尿病与一般人群队列进行比较。通过相对风险（RR）和方差分析（ANOVA），比较 3603 例 T1D 患儿的父母和（外）祖父母的糖尿病家族史，比较 T1D 患儿的临床特征。
结果
T1D 患儿的父母患 2 型糖尿病（T2D）的比例高于无糖尿病患儿（RR 1.88；P < 0.001）。有 T2D 家族史的 T1D 患儿更易超重或肥胖（P = 0.002）。
结论
T2D 家族史和超重可能增加 T1D 的风险。
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