Bayir Yasin, Erkayman Beyzagül, Albayrak Abdulmecit, Palabiyik-Yücelik Şaziye Sezin, Can Sümeyra, Hanci Hayrunisa, Tunç Fatih, Halici Hamza, Civelek Maide Sena, Sevim Melike, Yurdgülü Emir Enis, Metin Önder
Department of Biochemistry, Faculty of Pharmacy, Ataturk University, Erzurum, Türkiye.
Department of Pharmacology, Faculty of Pharmacy, Ataturk University, Erzurum, Türkiye.
J Biomater Appl. 2025 Jan;39(6):592-606. doi: 10.1177/08853282241268673. Epub 2024 Sep 20.
Boron, an essential element for human, can be a key factor in wound healing. For this reason, in this study, role of boron products (boric acid and zinc borate) and boron product doped new synthesized graphene hydrogels was investigated for burn healing via in vitro viability-biocompatibility tests and microbiological analysis. It has been determined that boric acid and zinc borate are effective against microbial agents that are frequently seen in burns. In L929 mouse fibroblast cell line, BA, ZB and graphene hydrogels did not show any toxic effects, either alone or doped Graphene Hydrogel forms, except at very high doses. These substances showed antioxidant properties by protecting cells against HO damage. The migration test performed on boron products also confirms the protective effect of boron products. In this study, the synthesis of graphene hydrogels was made for the first time, and their characterization was completed with appropriate instrumental analyses. The results of the biocompatibility tests of graphene hydrogels show that they are at least 96% biocompatible.
硼是人体必需的元素，可能是伤口愈合的关键因素。因此，在本研究中，通过体外活力-生物相容性测试和微生物分析，研究了硼产品（硼酸和硼酸锌）以及硼产品掺杂的新合成石墨烯水凝胶对烧伤愈合的作用。已确定硼酸和硼酸锌对烧伤中常见的微生物有效。在L929小鼠成纤维细胞系中，硼酸、硼酸锌和石墨烯水凝胶单独或掺杂石墨烯水凝胶形式时，除了非常高的剂量外，均未显示出任何毒性作用。这些物质通过保护细胞免受羟基自由基损伤而表现出抗氧化特性。对硼产品进行的迁移试验也证实了硼产品的保护作用。在本研究中，首次制备了石墨烯水凝胶，并通过适当的仪器分析完成了其表征。石墨烯水凝胶的生物相容性测试结果表明，它们的生物相容性至少为96%。
