School of Medical Sciences, The University of Sydney, Sydney, NSW 2006, Australia; Laboratory of Data Discovery for Health Limited, Hong Kong SAR, China.
Department of Microbiology, Icahn School of Medicine at Mount Sinai, New York, NY, USA; Center for Vaccine Research and Pandemic Preparedness (C-VaRPP), Icahn School of Medicine at Mount Sinai, New York, NY, USA; Department of Pathology, Molecular and Cell Based Medicine, Icahn School of Medicine at Mount Sinai, New York, NY, USA; Ignaz Semmelweis Institute, Interuniversity Institute for Infection Research, Medical University of Vienna, Vienna, Austria.
Cell. 2024 Sep 19;187(19):5128-5145. doi: 10.1016/j.cell.2024.07.025.
Virology has made enormous advances in the last 50 years but has never faced such scrutiny as it does today. Herein, we outline some of the major advances made in virology during this period, particularly in light of the COVID-19 pandemic, and suggest some areas that may be of research importance in the next 50 years. We focus on several linked themes: cataloging the genomic and phenotypic diversity of the virosphere; understanding disease emergence; future directions in viral disease therapies, vaccines, and interventions; host-virus interactions; the role of viruses in chronic diseases; and viruses as tools for cell biology. We highlight the challenges that virology will face moving forward-not just the scientific and technical but also the social and political. Although there are inherent limitations in trying to outline the virology of the future, we hope this article will help inspire the next generation of virologists.
在过去的 50 年里，病毒学取得了巨大的进步，但从未像今天这样受到如此严格的审查。在此，我们概述了这一时期病毒学取得的一些主要进展，特别是鉴于 COVID-19 大流行，我们还提出了未来 50 年可能具有研究重要性的一些领域。我们专注于几个相关主题：对病毒圈的基因组和表型多样性进行编目；了解疾病的出现；病毒疾病治疗、疫苗和干预措施的未来方向；宿主-病毒相互作用；病毒在慢性疾病中的作用；以及病毒作为细胞生物学工具。我们强调了病毒学未来将面临的挑战——不仅是科学和技术方面的，还有社会和政治方面的。尽管试图概述未来的病毒学存在固有局限性，但我们希望本文能够激励下一代病毒学家。
