Dhayanithi Chettipalayam Arunasalam, Babu Sundaram Ganesh
Nano-Catalysis Research Lab, Department of Chemistry, School of Advanced Sciences, Vellore Institute of Technology, Vellore, 632014, Tamilnadu, India.
Mikrochim Acta. 2024 Sep 21;191(10):611. doi: 10.1007/s00604-024-06692-8.
A novel electrochemical sensor is constructed by modifying the glassy carbon electrode (GCE) using a binder-free metal-organic framework of V-shaped linker 4,4'oxybis(benzoic acid) (OBA) and various transition metals (M-Zn, Mn, or Ni). The hydrothermally synthesized M-OBA MOFs demonstrated superior electron transfer ability and enhanced electro-reduction behaviour, making it highly effective for metronidazole (MTZ) detection. The optimized sensor demonstrated a linear response from 0.04 to 122.18 µM, a low detection limit (LOD) of 0.009 µM, and high sensitivity (0.48 µA µM cm) using cyclic voltammetry (CV) and differential pulse voltammetry (DPV). The sensor also exhibited excellent selectivity in the presence of various ions, organic compounds, and other antibiotics. The Zn-OBA MOF sensor proves practical applicability for detecting MTZ in milk, honey, tap water, and MTZ tablets.
通过使用V形连接体4,4'-氧基双苯甲酸（OBA）和各种过渡金属（M-Zn、Mn或Ni）的无粘合剂金属有机框架修饰玻碳电极（GCE），构建了一种新型电化学传感器。水热合成的M-OBA金属有机框架表现出优异的电子转移能力和增强的电还原行为，使其对甲硝唑（MTZ）检测非常有效。使用循环伏安法（CV）和差分脉冲伏安法（DPV），优化后的传感器在0.04至122.18 µM范围内呈现线性响应，检测限低至0.009 µM，灵敏度高（0.48 µA µM cm）。该传感器在存在各种离子、有机化合物和其他抗生素的情况下也表现出优异的选择性。Zn-OBA金属有机框架传感器证明了其在检测牛奶、蜂蜜、自来水和MTZ片剂中MTZ的实际适用性。
