College of Chemistry and Chemical Engineering, Guangxi Normal University for Nationalities, Chongzuo 532200, China; School of Pharmacy, Henan University of Traditional Chinese Medicine, Zhengzhou 450046, China.
School of Pharmacy, Henan University of Traditional Chinese Medicine, Zhengzhou 450046, China.
Biosens Bioelectron. 2018 May 30;106:212-218. doi: 10.1016/j.bios.2018.02.009.
In this study, we developed a novel photoelectrochemical (PEC) sensor for the highly sensitive detection of erythromycin by functionalising graphene oxide (GO) with nickel tetra-amined phthalocyanine (NiTAPc) through covalent bonding, which resulted in the formation of NiTAPc-Gr. The fabricated sensor showed a higher PEC efficiency under blue light, exhibiting a peak wavelength of 456 nm, as compared to that of the monomer. Further, the NiTAPc-Gr/indium tin oxide (ITO) sensor exhibited a photocurrent that was 50-fold higher than that for a GO/ITO sensor under the same conditions. Under optimal conditions, the NiTAPc-Gr PEC sensor showed a linear response for erythromycin concentrations ranging from 0.40 to 120.00 μmol L, with the minimum limit for detection being 0.08 μmol L. Thus, the NiTAPc-Gr sensor exhibited superior performance and excellent PEC characteristics, high stability, and good reproducibility with respect to the sensing of erythromycin. Moreover, it is convenient to use, fast, small, and cheap to produce. Hence, it should find wide use in the analysis of erythromycin in real-world applications.
在这项研究中，我们通过共价键将镍四氨基酞菁（NiTAPc）功能化到氧化石墨烯（GO）上，开发了一种用于高度灵敏检测红霉素的光电化学（PEC）传感器，形成了 NiTAPc-Gr。与单体相比，所制备的传感器在蓝光下表现出更高的 PEC 效率，其峰值波长为 456nm。此外，在相同条件下，NiTAPc-Gr/氧化铟锡（ITO）传感器的光电流比 GO/ITO 传感器高 50 倍。在最佳条件下，NiTAPc-Gr PEC 传感器对红霉素浓度在 0.40 至 120.00 μmol L 之间表现出线性响应，检测下限为 0.08 μmol L。因此，与红霉素的传感相比，NiTAPc-Gr 传感器表现出优异的性能和出色的 PEC 特性、高稳定性和良好的重现性。此外，它使用方便、快速、小巧且价格低廉。因此，它应该在实际应用中广泛用于红霉素的分析。
