Department of Clinical Medicine Research Centre, Binhai County People's Hospital, Yancheng, 224000, China.
Department of Geriatrics, Binhai County People's Hospital, Yancheng, 224000, China.
Sci Rep. 2024 Sep 20;14(1):21930. doi: 10.1038/s41598-024-72949-0.
The impact of vitamin B2 (riboflavin) intake on cognitive performance among older adults in the United States (US) remains inadequately understood. This study aimed to explore the association between vitamin B2 intake and cognitive performance among non-institutionalized elderly people in the US. Weighted logistic regression was used to evaluate the association between vitamin B2 intake and cognitive performance. Vitamin B2 intake was determined from the mean of two 24-hour dietary recall interviews. Three cognitive ability assessment tests, namely the Immediate Recall Test (IRT), Animal Fluency Test (AFT), and Digit Symbol Substitution Test (DSST), were performed. Participants included all older adults over 60 who underwent cognitive scoring, with cut-offs defined based on the lowest quartile (25th percentile) for each test (the cut-offs for the three scores were 15.625, 12, and 33, respectively). Sensitivity analysis, including dose-response curves, subgroup analyses, interaction effects, per 1 standard deviation (SD), recommended dietary allowance (RDA), and residual energy model analysis, were performed to solidify the solid association between vitamin B2 and cognitive performance. A total of 2893 individuals aged over 60 were included, with a mean age of 69 (7) years, and 46% were men. There was a significant association between vitamin B2 intake and all three cognitive scores (IRT, Odds Ratio = 0.77, 95% confidence interval: [0.65,0.92]; AFT, 0.75, [0.64,0.88]; DSST, 0.72, [0.59,0.88]). Moreover, vitamin B2 intake above the RDA reduced the risk of low cognitive performance (IRT, 0.66, [0.46,0.93]; AFT, 0.83, [0.62,1.11]; DSST, 0.65, [0.45,0.92]) compared to intake below the RDA. Dose-response curves indicated that higher vitamin B2 intake was negatively associated with the risk of low cognitive performance. Physical activity may modify the association between vitamin B2 and cognitive performance. Vitamin B2 intake was positively associated with cognitive performance among older adults. Adequate vitamin B2 intake could help protect cognitive function.
美国（US）老年人的维生素 B2（核黄素）摄入量对认知表现的影响仍了解不足。本研究旨在探索美国非机构化老年人维生素 B2 摄入量与认知表现之间的关系。使用加权逻辑回归评估维生素 B2 摄入量与认知表现之间的关联。维生素 B2 摄入量是从两次 24 小时膳食回忆访谈的平均值中确定的。进行了三项认知能力评估测试，即即时回忆测试（IRT）、动物流畅性测试（AFT）和数字符号替代测试（DSST）。参与者包括所有接受认知评分的 60 岁以上老年人，根据每个测试的最低四分位数（第 25 个百分位数）定义了截止值（三个分数的截止值分别为 15.625、12 和 33）。进行了敏感性分析，包括剂量反应曲线、亚组分析、交互作用效应、每 1 个标准差（SD）、推荐膳食允许量（RDA）和剩余能量模型分析，以巩固维生素 B2 与认知表现之间的牢固关联。共纳入 2893 名 60 岁以上老年人，平均年龄为 69（7）岁，46%为男性。维生素 B2 摄入量与所有三项认知评分（IRT，优势比 = 0.77，95%置信区间：[0.65，0.92]；AFT，0.75，[0.64，0.88]；DSST，0.72，[0.59，0.88]）均存在显著关联。此外，RDA 以上的维生素 B2 摄入量降低了认知表现较低的风险（IRT，0.66，[0.46，0.93]；AFT，0.83，[0.62，1.11]；DSST，0.65，[0.45，0.92]）与 RDA 以下的摄入量相比。剂量反应曲线表明，较高的维生素 B2 摄入量与认知表现较低的风险呈负相关。身体活动可能会改变维生素 B2 与认知表现之间的关系。维生素 B2 摄入量与老年人的认知表现呈正相关。充足的维生素 B2 摄入有助于保护认知功能。
