Wu Mengyao, Tao Huihui, Xu Tiantian, Zheng Xuejia, Wen Chunmei, Wang Guoying, Peng Yali, Dai Yong
School of Medicine, Anhui University of Science & Technology, Huainan, China.
Key Laboratory of Industrial Dust Deep Reduction and Occupational Health and Safety of Anhui Higher Education Institutes, Huainan, China.
Proteome Sci. 2024 Sep 20;22(1):7. doi: 10.1186/s12953-024-00231-2.
Spatial proteomics is a multidimensional technique that studies the spatial distribution and function of proteins within cells or tissues across both spatial and temporal dimensions. This field multidimensionally reveals the complex structure of the human proteome, including the characteristics of protein spatial distribution, dynamic protein translocation, and protein interaction networks. Recently, as a crucial method for studying protein spatial localization, spatial proteomics has been applied in the clinical investigation of various diseases. This review summarizes the fundamental concepts and characteristics of tissue-level spatial proteomics, its research progress in common human diseases such as cancer, neurological disorders, cardiovascular diseases, autoimmune diseases, and anticipates its future development trends. The aim is to highlight the significant impact of spatial proteomics on understanding disease pathogenesis, advancing diagnostic methods, and developing potential therapeutic targets in clinical research.
空间蛋白质组学是一种多维技术，可在空间和时间维度上研究细胞或组织内蛋白质的空间分布和功能。该领域从多个维度揭示了人类蛋白质组的复杂结构，包括蛋白质空间分布特征、蛋白质动态转位以及蛋白质相互作用网络。近年来，作为研究蛋白质空间定位的关键方法，空间蛋白质组学已应用于各种疾病的临床研究。本文综述了组织水平空间蛋白质组学的基本概念和特点，及其在癌症、神经疾病、心血管疾病、自身免疫性疾病等常见人类疾病中的研究进展，并展望了其未来发展趋势。目的是突出空间蛋白质组学在临床研究中对理解疾病发病机制、推进诊断方法以及开发潜在治疗靶点方面的重大影响。
