Amiri Sohrab, Ab Khan Moien
Medicine, Quran and Hadith Research Center, Baqiyatallah University of Medical Sciences, Tehran, Iran.
Health and wellness research group, Department of Family Medicine, College of Medicine and Health Sciences, United Arab Emirates University, Al Ain, UAE.
Eat Disord. 2024 Sep 21:1-35. doi: 10.1080/10640266.2024.2402634.
The aim of this study was a systematic review and meta-analysis of the relationship between eating disorders and mortality. Based on this, eating disorders were investigated concerning all causes of mortality. Information sources including PubMed, Scopus, and Web of Science were used based on a systematic search. Google Scholar and Research Gate were also searched. The search in these databases started without a time limit and was done until December 2023. This search was done in English. The results extracted were pooled together based on the Standardized Mortality Ratio (SMR) with a 95% confidence interval. The random effects method was used to pool studies together. An analysis was performed based on eating disorders and mortality, and the relationship between three types of eating disorders and mortality was reported as subgroups. Sixty studies were included in the meta-analysis. The obtained results showed that eating disorders have a significant relationship with the risk of mortality; SMR was 4.42 (CI 3.55-5.50; Z = 13.31; < .001; = 96.3%). Anorexia nervosa has a significant relationship with the risk of mortality, SMR was 5.31 (CI 4.15-6.79; Z = 13.30; < .001; = 93.1%). For bulimia nervosa the risk of mortality was SMR 2.69 (CI 1.85-3.91; Z = 5.16; < .001; = 66.6%). For eating disorders not otherwise specified the risk of mortality was SMR 2.50 (CI 1.45-4.33; Z = 3.28; = .001; = 91.8%). From the findings of this research, it was determined how serious the risk of death is in patients with eating disorders. Therefore, it is necessary to pay more attention to this issue in the processes of prevention, screening, and treatment of eating disorders.
本研究的目的是对饮食失调与死亡率之间的关系进行系统评价和荟萃分析。基于此，对饮食失调的所有死亡原因进行了调查。基于系统检索，使用了包括PubMed、Scopus和Web of Science在内的信息来源。还搜索了谷歌学术和Research Gate。这些数据库的检索没有时间限制，一直持续到2023年12月。检索以英文进行。提取的结果根据标准化死亡率（SMR）及95%置信区间进行汇总。采用随机效应方法对研究进行汇总。基于饮食失调和死亡率进行了分析，并报告了三种饮食失调类型与死亡率之间的关系作为亚组。荟萃分析纳入了60项研究。获得的结果表明，饮食失调与死亡风险存在显著关系；标准化死亡率为4.42（置信区间3.55 - 5.50；Z = 13.31；P <.001；I² = 96.3%）。神经性厌食症与死亡风险存在显著关系，标准化死亡率为5.31（置信区间4.15 - 6.79；Z = 13.30；P <.001；I² = 93.1%）。对于神经性贪食症，死亡风险的标准化死亡率为2.69（置信区间1.85 - 3.91；Z = 5.16；P <.001；I² = 66.6%）。对于未另行指定的饮食失调，死亡风险的标准化死亡率为2.50（置信区间1.45 - 4.33；Z = 3.28；P =.001；I² = 91.8%）。从本研究的结果可以确定饮食失调患者的死亡风险有多严重。因此，在饮食失调的预防、筛查和治疗过程中，有必要更加关注这个问题。
