Johnston C C, Hui S L, Witt R M, Appledorn R, Baker R S, Longcope C
J Clin Endocrinol Metab. 1985 Nov;61(5):905-11. doi: 10.1210/jcem-61-5-905.
Eighty-four healthy perimenopausal and early postmenopausal women were divided into four groups: group A, those with slightly irregular menstrual periods and plasma FSH below 40 mIU/ml; group B, those with irregular periods and FSH above 40 mIU/ml; group C, those whose last menstrual period was within 1 yr of study; and, group D, those whose last menstrual period was between 12 and 55 months before the study. Plasma concentrations of estrone and estradiol progressively decreased in groups B, C and D compared to those in A in parallel with a decrease in the production rates, and FSH and LH were significantly increased. There was little change in the concentration of androstenedione or testosterone. Vertebral bone mass was significantly decreased in groups B, C, and D compared to that in A, and radial bone mass was decreased in group D. There was a significantly positive correlation between plasma estrone and estradiol and bone mass at both the radius and vertebra. Increased bone remodeling was suggested by increases in serum calcium and bone gla protein. These data suggest that bone loss, at least from the spine, may begin before menses cease and is correlated with decreases in estrogen production and increases in bone remodeling.
84名健康的围绝经期和绝经早期女性被分为四组：A组，月经周期轻度不规律且血浆促卵泡激素（FSH）低于40 mIU/ml；B组，月经周期不规律且FSH高于40 mIU/ml；C组，末次月经在研究开始后1年内；D组，末次月经在研究开始前12至55个月。与A组相比，B、C、D组中雌酮和雌二醇的血浆浓度随着生成率的降低而逐渐下降，促卵泡激素（FSH）和促黄体生成素（LH）显著升高。雄烯二酮或睾酮浓度变化不大。与A组相比，B、C、D组的椎骨骨量显著降低，D组的桡骨骨量降低。血浆雌酮和雌二醇与桡骨和椎骨的骨量之间存在显著正相关。血清钙和骨钙素升高提示骨重塑增加。这些数据表明，至少从脊柱开始的骨质流失可能在月经停止前就已开始，并且与雌激素生成减少和骨重塑增加相关。
