State Key Laboratory of Component-based Modern Chinese Medicine, Tianjin University of Traditional Chinese Medicine, Tianjin 301617, China.
School of Pharmacy, Tianjin Medical University, Tianjin 300070, China.
Biomed Pharmacother. 2021 Jan;133:111044. doi: 10.1016/j.biopha.2020.111044. Epub 2020 Dec 11.
Traditional Chinese Medicine (TCM) has the characteristics of multiple targets, slight side effects and good therapeutic effects. Good anti-tumor effects are shown by Traditional Chinese Medicine prescription, Chinese patent medicine, single Traditional Chinese Medicine and Traditional Chinese medicine monomer compound. Clinically, TCM prolonged the survival time of patients and improved the life quality of patients, due to less side effects. Cancer metastasis is a complex process involving numerous steps, multiple genes and their products. During the process of tumor metastasis, firstly, cancer cell increases its proliferative capacity by reducing autophagy and apoptosis, and then the cancer cell capacity is stimulated by increasing the ability of tumors to absorb nutrients from the outside through angiogenesis. Both of the two steps can increase tumor migration and invasion. Finally, the purpose of tumor metastasis is achieved. By inhibiting autophagy and apoptosis of tumor cells, angiogenesis and EMT outside the tumor can inhibit the invasion and migration of cancer, and consequently achieve the purpose of inhibiting tumor metastasis. This review explores the research achievements of Traditional Chinese Medicine on breast cancer, lung cancer, hepatic carcinoma, colorectal cancer, gastric cancer and other cancer metastasis in the past five years, summarizes the development direction of TCM on cancer metastasis research in the past five years and makes a prospect for the future.
中医（TCM）具有多靶点、副作用小、疗效好的特点。中药方剂、中药成药、单味中药及中药单体化合物均表现出良好的抗肿瘤作用。临床上，由于副作用较小，中医药延长了患者的生存时间，提高了患者的生活质量。癌症转移是一个涉及多个步骤、多个基因及其产物的复杂过程。在肿瘤转移过程中，首先，癌细胞通过减少自噬和细胞凋亡来增加其增殖能力，然后通过增加肿瘤从外部吸收营养的能力来刺激癌细胞的能力，从而促进血管生成。这两个步骤都可以增加肿瘤的迁移和侵袭。最后，实现肿瘤转移的目的。通过抑制肿瘤细胞的自噬和细胞凋亡、肿瘤外的血管生成和 EMT，可以抑制癌症的侵袭和迁移，从而达到抑制肿瘤转移的目的。本综述探讨了过去五年中医在乳腺癌、肺癌、肝癌、结直肠癌、胃癌等癌症转移方面的研究成果，总结了过去五年中医在癌症转移研究方面的发展方向，并对未来进行了展望。
