Chen Linzi, Wang Zhongjie, Xiao Ningkun, Liu Jinhui, Tao Yuhan, Zhang Sifang
Department of Integrated Traditional Chinese & Western Medicine, The Second Xiangya Hospital, Central South University, Changsha, Hunan, China.
Department of Immunochemistry, Institution of Chemical Engineering, Ural Federal University, Yekaterinburg, Russia.
Front Oncol. 2025 Jun 16;15:1591257. doi: 10.3389/fonc.2025.1591257. eCollection 2025.
Colorectal cancer (CRC) is a leading cause of global cancer mortality, increasingly linked to circadian rhythm disruption-a critical yet underexplored driver of tumorigenesis.
This bibliometric analysis evaluates 374 publications from the Web of Science Core Collection (1999-2024) using VOSviewer, CiteSpace, and Bibliometrix to map global research trends.
Annual publications surged post-2016, peaking in 2021, reflecting intensified focus on circadian-CRC interactions. The United States led in output (122 publications, H-index 46), followed by France (76 publications) and China (49 publications), with the Netherlands achieving the highest citation impact (88.06 citations per publication). French institutions, notably Assistance Publique-Hôpitaux de Paris (APHP), dominated translational research, while foundational studies by Levi et al. on chronomodulated chemotherapy remained pivotal. Keyword analysis identified "circadian rhythm" and "colorectal cancer" as core themes, with "inflammation" and "inflammatory bowel disease" showing significant citation bursts post-2014. Co-citation networks bridged molecular chronobiology (Science, PNAS) and clinical oncology (Cancer Research), though mechanistic studies prioritized clock genes (e.g., BMAL1, PER2) over environmental disruptors. Clinically, aligning chemotherapy with circadian rhythms reduced severe toxicity by 40% in metastatic CRC, yet gaps persist in biomarker validation and monitoring tools. Epidemiologically, shift workers faced a 20-30% elevated CRC risk, correlating with PER2 silencing in 45% of tumors and NF-κB/STAT3 pathway activation.
Future research should integrate AI-driven circadian profiling, global collaboration, and trials targeting circadian-immune-metabolic axes to advance precision chronotherapy. This study underscores circadian biology as a cornerstone of CRC management, advocating strategies that harmonize molecular insights with ecological relevance to improve outcomes.
结直肠癌（CRC）是全球癌症死亡的主要原因，越来越多地与昼夜节律紊乱相关——这是肿瘤发生的一个关键但尚未充分探索的驱动因素。
本文献计量分析使用VOSviewer、CiteSpace和Bibliometrix对来自科学网核心合集（1999 - 2024年）的374篇出版物进行评估，以绘制全球研究趋势。
2016年后年度出版物数量激增，在2021年达到峰值，反映出对昼夜节律与结直肠癌相互作用的关注度增强。美国在产出方面领先（122篇出版物，H指数46），其次是法国（76篇出版物）和中国（49篇出版物），荷兰的引文影响力最高（每篇出版物88.06次引文）。法国机构，尤其是巴黎公立医院集团（APHP），在转化研究方面占主导地位，而 Levi等人关于时辰调制化疗的基础研究仍然至关重要。关键词分析确定“昼夜节律”和“结直肠癌”为核心主题，“炎症”和“炎症性肠病”在2014年后显示出显著的引文爆发。共被引网络连接了分子生物钟学（《科学》《美国国家科学院院刊》）和临床肿瘤学（《癌症研究》），尽管机制研究优先考虑生物钟基因（如BMAL1、PER2）而非环境干扰因素。在临床上，使化疗与昼夜节律同步可将转移性结直肠癌的严重毒性降低40%，但在生物标志物验证和监测工具方面仍存在差距。在流行病学上，轮班工作者患结直肠癌的风险升高20 - 30%，与45%的肿瘤中PER2沉默以及NF-κB/STAT3通路激活相关。
未来的研究应整合人工智能驱动的昼夜节律分析、全球合作以及针对昼夜节律 - 免疫 - 代谢轴的试验，以推进精准时辰疗法。本研究强调昼夜节律生物学是结直肠癌管理的基石，倡导将分子见解与生态相关性相结合的策略以改善治疗效果。
