Eversole L R, Belton C M, Hansen L S
J Oral Pathol. 1985 Sep;14(8):603-14. doi: 10.1111/j.1600-0714.1985.tb00537.x.
Clear cell odontogenic tumor, a rare epithelial jaw lesion of putative odontogenic origin, histologically resembles clear cell adenocarcinomas. Ultrastructural and histochemical features are described and support a non-glandular derivation. The intraosseous neoplasm is characterized by ovoid nests of clear or finely stippled cells with a mature collagenous stroma. These cells are PAS-positive, diastase labile and fail to bind alcian blue. Enzyme histochemical reactions disclose dehydrogenase, non-specific esterase, and acid phosphatase positivity. Fine structural characteristics include plasma membrane microvilli, desmosomes, endoplasmic reticulum, free ribosomes, glycogen rosettes and lysosomes. Many cells exhibit a paucity of cytoplasmic organelles with prominent vacuolization. Centrioles and annulate lamellae are also encountered. Summarily, clinical, radiographic, histochemical and ultrastructural features indicate that this neoplasm is probably of epithelial odontogenic origin with cytodifferentiation emulating glycogen-rich presecretory ameloblasts.
透明细胞牙源性肿瘤是一种罕见的颌骨上皮性病变，推测起源于牙源性，组织学上类似于透明细胞腺癌。本文描述了其超微结构和组织化学特征，并支持其非腺源性。骨内肿瘤的特征是由透明或细点状细胞组成的卵圆形巢团，伴有成熟的胶原性基质。这些细胞对PAS呈阳性反应，不耐淀粉酶，且不结合阿尔辛蓝。酶组织化学反应显示脱氢酶、非特异性酯酶和酸性磷酸酶呈阳性。精细结构特征包括质膜微绒毛、桥粒、内质网、游离核糖体、糖原玫瑰花结和溶酶体。许多细胞的细胞质细胞器稀少，空泡化明显。还可见中心粒和环层板。总之，临床、影像学、组织化学和超微结构特征表明，该肿瘤可能起源于牙源性上皮，细胞分化类似于富含糖原的分泌前期成釉细胞。
