Influence of gonadectomy on isoelectrofocusing profiles of pituitary gonadotropins in rhesus monkeys.

Isoelectrofocusing (IEF) profiles of bioactive and immunoreactive follicle-stimulating hormone (FSH) and luteinizing hormone (LH) were studied in saline extracts of pituitary glands from rhesus monkeys. No sex differences were found in the IEF profiles of FSH and LH in intact or gonadectomized animals. Gonadectomy in both sexes resulted in a marked increase in the formation of relatively more acidic molecular species of FSH and LH in parallel with the production of an unusual strongly alkaline FSH species.