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雄性恒河猴阉割后垂体促性腺激素的质性变化。

Qualitative changes in the pituitary gonadotropins of the male Rhesus monkey following castration.

作者信息

Peckham W D, Knobil E

出版信息

Endocrinology. 1976 Apr;98(4):1061-4. doi: 10.1210/endo-98-4-1061.

DOI:10.1210/endo-98-4-1061
PMID:819247
Abstract

Characterization of pituitary LH and FSH from intact and castrated male monkeys showed that gonadotropins from intact males are smaller in average apparent molecular size, and disappear from the circulation of test rats more rapidly than hormones from castrated males. Furthermore, intact male monkey LH and FSH are smaller and are cleared from the rat circulation faster than the gonadotropins from intact female monkeys. We conclude that 1) in the rhesus monkey changes in the properties of pituitary LH and FSH resulting from orchidectomy are similar to those which follow ovariectomy, 2) the response to gonadectomy of the male monkey with regard to the molecular properties of FSH is opposite to that of the male rat, and 3) the relationship between the influence of male and female sex hormones on the apparent molecular size of FSH in the monkey is the reverse of that in the rat.

摘要

对完整雄性和阉割雄性猴子垂体促黄体生成素(LH)和促卵泡生成素(FSH)的特性研究表明,完整雄性猴子的促性腺激素平均表观分子大小较小,并且从受试大鼠的循环中消失的速度比阉割雄性猴子的激素更快。此外,完整雄性猴子的LH和FSH比完整雌性猴子的促性腺激素更小,从大鼠循环中清除的速度更快。我们得出以下结论:1)在恒河猴中,睾丸切除导致的垂体LH和FSH特性变化与卵巢切除后的变化相似;2)雄性猴子对性腺切除在FSH分子特性方面的反应与雄性大鼠相反;3)雄性和雌性性激素对猴子FSH表观分子大小的影响关系与大鼠相反。

相似文献

1
Qualitative changes in the pituitary gonadotropins of the male Rhesus monkey following castration.雄性恒河猴阉割后垂体促性腺激素的质性变化。
Endocrinology. 1976 Apr;98(4):1061-4. doi: 10.1210/endo-98-4-1061.
2
The effects of ovariectomy, estrogen replacement, and neuraminidase treatment on the properties of the adenohypophysial glycoprotein hormones of the Rhesus monkey.卵巢切除术、雌激素替代疗法及神经氨酸酶处理对恒河猴腺垂体糖蛋白激素特性的影响。
Endocrinology. 1976 Apr;98(4):1054-60. doi: 10.1210/endo-98-4-1054.
3
A striking sex difference in the gonadotropin response to gonadectomy during infantile development in the rhesus monkey (Macaca mulatta).恒河猴(猕猴属)幼年期发育过程中,性腺切除术后促性腺激素反应存在显著的性别差异。
Endocrinology. 1986 Aug;119(2):539-45. doi: 10.1210/endo-119-2-539.
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Influence of gonadectomy on isoelectrofocusing profiles of pituitary gonadotropins in rhesus monkeys.
J Med Primatol. 1985;14(4):177-94.
5
Morphometric studies of rat anterior pituitary cells after gonadectomy: correlation of changes in gonadotropes with the serum levels of gonadotropins.去势大鼠垂体前叶细胞的形态计量学研究:促性腺激素细胞变化与促性腺激素血清水平的相关性。
Endocrinology. 1986 Aug;119(2):629-37. doi: 10.1210/endo-119-2-629.
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Effects of orchidectomy on gonadotropin and inhibin subunit messenger ribonucleic acids in the pituitary of the rhesus monkey (Macaca mulatta).睾丸切除术对恒河猴(猕猴)垂体中促性腺激素和抑制素亚基信使核糖核酸的影响。
Endocrinology. 1992 Mar;130(3):1238-44. doi: 10.1210/endo.130.3.1537290.
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Bioassay of circulating luteinizing hormone in the rhesus monkey: comparison with radioimmunoassay during physiological changes.恒河猴循环促黄体生成素的生物测定:生理变化期间与放射免疫测定的比较。
Endocrinology. 1977 Jun;100(6):1557-65. doi: 10.1210/endo-100-6-1557.
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Evidence from the rhesus monkey (Macaca mulatta) for the view that negative feedback control of luteinizing hormone secretion by the testis is mediated by a deceleration of hypothalamic gonadotropin-releasing hormone pulse frequency.恒河猴(猕猴)的证据支持以下观点:睾丸对促黄体生成素分泌的负反馈控制是通过下丘脑促性腺激素释放激素脉冲频率的减慢来介导的。
Endocrinology. 1984 Dec;115(6):2145-53. doi: 10.1210/endo-115-6-2145.
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Effect of active and passive immunization with luteinizing hormone-releasing hormone on serum luteinizing hormone and follicle-stimulating hormone levels and the ultrastructure of the pituitary gonadotrophs in castrated male rats.促黄体生成素释放激素主动免疫和被动免疫对去势雄性大鼠血清促黄体生成素和促卵泡激素水平及垂体促性腺细胞超微结构的影响
Endocrinology. 1976 Jul;99(1):291-303. doi: 10.1210/endo-99-1-291.
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The effects of neonatal orchidectomy on the developmental pattern of gonadotropin secretion in the male rhesus monkey (Macaca mulatta).新生期睾丸切除术对雄性恒河猴(猕猴)促性腺激素分泌发育模式的影响。
Endocrinology. 1980 May;106(5):1451-4. doi: 10.1210/endo-106-5-1451.

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Biochem J. 1982 Jun 1;203(3):653-62. doi: 10.1042/bj2030653.
2
Dissociated effect of buserelin on luteinizing hormone (LH) and alpha subunit in men.布舍瑞林对男性促黄体生成素(LH)和α亚基的解离作用。
J Endocrinol Invest. 1990 Jun;13(6):459-67. doi: 10.1007/BF03348599.
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Changes in the sialylation and sulfation of secreted thyrotropin in congenital hypothyroidism.先天性甲状腺功能减退症中分泌型促甲状腺激素唾液酸化和硫酸化的变化。
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