[Research pro gress on historical processing evolution, chemical constituents,and pharmacological effects of Plantaginis Semen].

Plantaginis Semen is a traditional Chinese medicine(TCM) commonly used in clinical practice in China, which has the effects of clearing heat, inducing diuresis for treating stranguria, draining dampness and relieving diarrhea, brightening eyes, and eliminating phlegm. Plantaginis Semen has a long history of processing. In the Han Dynasty, there were records of stir-frying, and then processing with wine, processing with salt water, processing with rice water, and other processing methods appeared. Plantaginis Semen after processing can weaken the cold nature of the drug, suitable for clinical application. Modern research has shown that the main chemical constituents of Plantaginis Semen are phenylethanol glycosides, cyclic enol ether terpenes, polysaccharides, and flavonoids, with diuretic, anti-inflammatory, hypoglycemic, hypolipidemic, antioxidant, and other pharmacological effects. This article reviewed the materia medica, medicine books, and related literature in various dynasties and analyzed the historical processing evolution, chemical constituents, and pharmacological effects of Plantaginis Semen, so as to provide a reference for the relevant research on Plantaginis Semen.