Zhang Zhi-Jun, Gao Ru, Lu Yu-Tong, Zuo Zhi-Liang, Li Yu-Huan, Liu Shan, Song Si-Yuan, Wang Yi, Lai Hongyan
Hepatological surgery department, The People's Hospital of Wenjiang Chengdu, Chengdu, China.
Nursing Department, The People's Hospital of Wenjiang Chengdu, Chengdu, China.
Front Cell Infect Microbiol. 2025 Mar 24;15:1529347. doi: 10.3389/fcimb.2025.1529347. eCollection 2025.
As the population ages, intestinal health in the elderly has become a key area of concern, with gut microbiota dysbiosis emerging as a significant issue. This review summarizes the factors influencing dysbiosis and interventions from both traditional Chinese medicine (TCM) and Western medicine, offering a reference for future research. A comprehensive search of global databases up to March 2024 identified 617 original studies on gut microbiota dysbiosis in individuals aged 65 and older. After applying strict PRISMA guidelines, 20 articles met the inclusion criteria. Key findings are summarized in four areas: 1) the definition and mechanisms of dysbiosis, 2) evaluation tools for gut microbiota imbalance, 3) factors contributing to dysbiosis in the elderly, and 4) pharmacological treatments. Both TCM and Western medicine offer unique advantages in managing gut microbiota dysbiosis, and the choice of intervention should be tailored to the individual's condition. Future research should focus on optimizing integrated TCM and Western medicine approaches to improve outcomes for elderly patients with gut microbiota dysbiosis.
随着人口老龄化，老年人的肠道健康已成为一个关键的关注领域，肠道微生物群失调成为一个重大问题。本综述总结了影响失调的因素以及中医和西医的干预措施，为未来的研究提供参考。对截至2024年3月的全球数据库进行全面检索，确定了617项关于65岁及以上个体肠道微生物群失调的原始研究。在应用严格的PRISMA指南后，有20篇文章符合纳入标准。主要研究结果总结为四个方面：1）失调的定义和机制，2）肠道微生物群失衡的评估工具，3）导致老年人失调的因素，4）药物治疗。中医和西医在管理肠道微生物群失调方面都具有独特优势，干预措施的选择应根据个体情况量身定制。未来的研究应侧重于优化中西医结合方法，以改善老年肠道微生物群失调患者的治疗效果。
