褐藻糖胶对 Wistar 大鼠细胞和体液免疫应答的免疫刺激作用。
The immunostimulatory effects of fucoidan on the cellular and humoral immune response in Wistar rats.
机构信息
Department of Basic Veterinary Medicine, Faculty of Veterinary Medicine, Airlangga University, Surabaya, Indonesia.
Program Study of Pharmacy, Faculty of Medicine, Hang Tuah University, Surabaya, Indonesia.
出版信息
Open Vet J. 2024 Aug;14(8):1794-1800. doi: 10.5455/OVJ.2024.v14.i8.7. Epub 2024 Aug 31.
BACKGROUND
Natural product active ingredients are currently being studied rigorously worldwide and offer a viable substitute for traditional immunotherapy for various medical disorders.
AIM
The objective of the study was to investigate the immunostimulatory properties of fucoidan in albino Wistar rats.
METHODS
For the current study, forty rats were divided into five groups of rats that were used in good condition. In-vivo experiments of fucoidan were carried out in Wistar albino rats, such as the cyclophosphamide-caused myelosuppression, the delayed-type hypersensitivity (DTH) response, the phagocytic activity, the haemagglutinating antibody (HA) titer, and the neutrophil adhesion test.
RESULTS
The phagocytic index increased significantly in response to Fucoidan in a dose-dependent manner, as well as enhanced DTH reaction, and HA titer caused by sheep red blood cells sheep red blood cells. Additionally, fucoidan decreased myelosuppression in rats after cyclophosphamide treatment and enhanced neutrophil adhesion with nylon fiber.
CONCLUSION
These findings imply that fucoidan has immunostimulant properties and could potentially utilised to treat immune-depression diseases.
背景
天然产物活性成分目前正在全球范围内进行严格研究，为各种医学疾病的传统免疫疗法提供了可行的替代品。
目的
本研究旨在探讨褐藻糖胶在白化 Wistar 大鼠中的免疫刺激特性。
方法
在这项研究中，将四十只大鼠分为五组，每组均使用状况良好的大鼠。在 Wistar 白化大鼠中进行褐藻糖胶的体内实验，如环磷酰胺引起的骨髓抑制、迟发型超敏反应（DTH）反应、吞噬活性、血凝抗体（HA）效价和中性粒细胞黏附试验。
结果
褐藻糖胶呈剂量依赖性地显著增加吞噬指数，增强 DTH 反应以及由绵羊红细胞引起的 HA 效价。此外，褐藻糖胶可降低环磷酰胺处理后大鼠的骨髓抑制，并增强尼龙纤维上的中性粒细胞黏附。
结论
这些发现表明褐藻糖胶具有免疫刺激特性，可用于治疗免疫抑制性疾病。
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