Basic Sciences Branch, College of Dentistry Medicine, University of Al-Qadisiyah, Diwaniyah, Iraq.
Community Health Technologies Department, Technical Institute of Al-Diwaniyah, AL-Furat AL Awsat Technical University, Diwaniyah, Iraq.
Open Vet J. 2024 Aug;14(8):1928-1935. doi: 10.5455/OVJ.2024.v14.i8.21. Epub 2024 Aug 31.
The most widespread condition that affected on primarily the male population is Benign hyperplasia of the prostate benign prostatic hyper-plasia (BPH). Flax seeds have been reported to have antiproliferation properties and exhibit antitumor.
We assessed the impact of flax seeds ethanolic excerpt on BPH within a testosterone propionate (TP)-induced model of rats.
A pre-3-week daily injection of TP (3 mg/kg BW) was used to induce BPH. Twenty male rats (200-240 gm) were randomly divided into 4 equal groups ( = 5) negative Group under control was given PBS orally, corn oil S/C, BPH-induced rats received 3 mg/kg BW TP for 3 weeks, extract group received 50 mg/Kg extract twice daily for 2 weeks Finasteride group received standard drug 10 mg/Kg BW for 2 weeks. When the course of treatment is over, rats were sacrificed and the blood was collected and separated, the prostate of the rats was harvested for histological examination.
The results showed that flax seeds ethanolic extract could significantly ( < 0.05) reduce the prostate gland weight, prostate index, serum level of PAS, testosterone, and 5-a reductase enzyme in BPH-induced rats and improve the tissue morphology of the prostate.
Based on our results, the extract suggested that have a promising role in the treatment of benign hyperplasia of the prostate.
最普遍的影响主要是男性人群的疾病是良性前列腺增生症（BPH）。亚麻籽已被报道具有抗增殖特性，并表现出抗肿瘤作用。
我们评估了亚麻籽油醇提取物对丙酸睾酮（TP）诱导的大鼠良性前列腺增生症（BPH）的影响。
使用 3 周的每日 TP（3 mg/kg BW）预注射来诱导 BPH。将 20 只雄性大鼠（200-240 gm）随机分为 4 组（每组 5 只）：阴性对照组给予 PBS 口服，玉米油 S/C，BPH 诱导组给予 3 mg/kg BW TP 3 周，提取物组给予 50 mg/Kg 提取物每日 2 次，共 2 周；非那雄胺组给予标准药物 10 mg/Kg BW，共 2 周。治疗结束后，处死大鼠，采集血液并分离，采集大鼠前列腺进行组织学检查。
结果表明，亚麻籽油醇提取物能显著（<0.05）降低前列腺重量、前列腺指数、血清 PAS、睾酮和 5-a 还原酶水平，改善前列腺组织形态。
根据我们的结果，提取物提示在治疗良性前列腺增生症方面具有有前景的作用。
