Bogdanovich A I, Tarasov N F, Korsunskiĭ V N
Med Radiol (Mosk). 1985 Sep;30(9):41-6.
A study was made of the biological distribution of 131I labeled stains and 99mTc labeled iminodiacetic acid derivatives in 153 patients of whom 98 suffered from jaundice of different genesis. Significant differences of their behavior in the human body depending on the chemical structure of the compound were revealed. Blood clearance for the iminodiacetic acid derivatives was 1.5-2 times as high as compared to that for the labeled stains. The rate of transit via the hepatocyte was the highest in 99mTc-MESIDA (USSR) 99mTc-DIDA and 99mTc-TIDA. The rate and volume of the renal excretion of the radiopharmaceutical depended on the main substance molecular structure. Retarded blood clearance lowered excretion of the radiopharmaceuticals by the liver and their considerable excretion with urine were observed. The Soviet radiopharmaceuticals 99mTc-MESIDA and 99mTc-BUTILIDA by their pharmacokinetic characteristics and quality were in no way inferior to the best foreign analogs.
对153例患者进行了研究，其中98例患有不同病因的黄疸，研究了131I标记物和99mTc标记的亚氨基二乙酸衍生物的生物分布。结果显示，根据化合物的化学结构，它们在人体内的行为存在显著差异。亚氨基二乙酸衍生物的血液清除率比标记物高1.5至2倍。99mTc-MESIDA（苏联）、99mTc-DIDA和99mTc-TIDA通过肝细胞的转运速率最高。放射性药物的肾脏排泄速率和量取决于主要物质的分子结构。观察到血液清除延迟会降低肝脏对放射性药物的排泄，并使其大量经尿液排泄。苏联的放射性药物99mTc-MESIDA和99mTc-BUTILIDA在药代动力学特性和质量方面绝不逊色于国外最好的类似物。
