Akcilar Raziye, Kocak Fatma Emel, Kar Fatih, Isiklar Ozben Ozden, Atlanoglu Sahinde, Genc Ozlem, Yaman Fatima
Department of Physiology, Kütahya Health Sciences University, Faculty of Medicine, Kutahya 43100, Turkey.
Department of Medical Biochemistry, Kütahya Health Sciences University, Faculty of Medicine, Kutahya 43100, Turkey.
Asian Biomed (Res Rev News). 2024 Sep 20;18(4):157-170. doi: 10.2478/abm-2024-0022. eCollection 2024 Aug.
The SARS-CoV-2 virus produces severe acute respiratory syndrome. The severity of coronavirus disease 2019 (COVID-19) infection is determined by a number of factors, including inherited ones.
Our goal is to investigate the link between (rs2285666) and (rs14035430) gene polymorphisms in COVID-19 patients with and without lung involvement.
A total of 160 COVID-19 patients were divided into 2 groups based on their clinical symptoms: those without lung involvement (control group) and those with lung involvement (infected group). The and gene polymorphisms were analyzed using the PCR-RFLP methods.
The GG genotype, G allele of , and GG genotype of were significantly higher in the control group and had a protective effect against COVID-19 as well as decreased the development of lung involvement (OR = 0.29, 95% CI = 0.10-0.84; OR = 0.40, 95% CI = 0.22-0.72; and OR = 0.33, 95% CI = 0.14-0.78, respectively). Moreover, we found that the AA genotype, A allele of , and AG genotype of increased the risk of COVID-19 in the infected group (OR = 3.50, 95% CI = 1.18-10.3; OR = 2.49, 95% CI = 1.39-4.48; and OR = 3.08, 95% CI = 1.28-7.38, respectively).
These results revealed that a greater frequency of COVID-19 lung involvement in the Turkish population was connected with the AA genotype, the A allele of , and the AG genotype of .
严重急性呼吸综合征冠状病毒2型（SARS-CoV-2）会引发严重急性呼吸综合征。2019冠状病毒病（COVID-19）感染的严重程度由多种因素决定，包括遗传因素。
我们的目标是研究COVID-19患者中有无肺部受累情况与（rs2285666）和（rs14035430）基因多态性之间的联系。
根据临床症状将160例COVID-19患者分为两组：无肺部受累者（对照组）和有肺部受累者（感染组）。采用聚合酶链反应-限制性片段长度多态性（PCR-RFLP）方法分析和基因多态性。
对照组中，的GG基因型、G等位基因以及的GG基因型显著更高，对COVID-19具有保护作用，并减少了肺部受累的发生（比值比[OR]=0.29，95%置信区间[CI]=0.10-0.84；OR=0.40，95%CI=0.22-0.72；以及OR=0.33，95%CI=0.14-0.78）。此外，我们发现，感染组中，的AA基因型、A等位基因以及的AG基因型增加了COVID-19的发病风险（OR=3.50，95%CI=1.18-10.3；OR=2.49，95%CI=1.39-4.48；以及OR=3.08，95%CI=1.28-7.38）。
这些结果表明，土耳其人群中COVID-19肺部受累发生率较高与的AA基因型、的A等位基因以及的AG基因型有关。
