Oncology Department, Liaocheng People's Hospital, Liaocheng, China.
Intervention Therapy Department, Liaocheng People's Hospital, Liaocheng, China.
Bioengineered. 2022 Apr;13(4):8526-8537. doi: 10.1080/21655979.2022.2051839.
Colorectal cancer (CRC) showed high cancer-related mortality in recent years partly due to the absence of an effective prognostic predictor. This research intended to evaluate the prognostic value and potential role of long intergenic non-protein coding RNA 1094 (LINC01094) in CRC. In this work, we evaluated the LINC01094 level in 122 CRC patients' tissues and in human CRC cell lines. We explored the ability of LINC01094 in overall survival and progression-free survival estimate. The effect of LINC01094 dysregulation on the CRC cells was investigated. LINC01094 is highly expressed in CRC tissues and cells than normal ones. This high expression was correlated with absent vascular invasion, positive lymph node metastasis, and advanced TNM stage. With the result of Kaplan-Meier analysis and multivariate Cox's proportional hazard analysis, LINC01094 was an effective biomarker for CRC overall survival. Downregulation of LINC01094 impeded the malignant biological behavior (proliferation, invasion, and migration) of CRC cells, while overexpression of LINC01094 boosted that maybe by sponging miR-1266-5p. LINC01094 might function as an oncogene in CRC and allowed the discovery of a new biomarker for prognosis and therapy of CRC.
结直肠癌（CRC）近年来的癌症相关死亡率较高，部分原因是缺乏有效的预后预测因子。本研究旨在评估长链非编码 RNA 1094（LINC01094）在 CRC 中的预后价值和潜在作用。在这项工作中，我们评估了 122 例 CRC 患者组织和人 CRC 细胞系中的 LINC01094 水平。我们探讨了 LINC01094 对总生存和无进展生存估计的能力。研究了 LINC01094 失调对 CRC 细胞的影响。LINC01094 在 CRC 组织和细胞中的表达高于正常组织和细胞。这种高表达与无血管侵犯、阳性淋巴结转移和晚期 TNM 分期相关。通过 Kaplan-Meier 分析和多变量 Cox 比例风险分析的结果，LINC01094 是 CRC 总生存的有效生物标志物。下调 LINC01094 抑制了 CRC 细胞的恶性生物学行为（增殖、侵袭和迁移），而 LINC01094 的过表达可能通过海绵吸附 miR-1266-5p 来促进这种行为。LINC01094 可能在 CRC 中作为癌基因发挥作用，并为 CRC 的预后和治疗发现了一个新的生物标志物。
