Eshun Gaddi B, Osonga Francis J, Sadik Omowunmi A
Department of Chemistry and Environmental Science BioSMART Center, New Jersey Institute of Technology, University Heights, 151 Warren Street, Newark, New Jersey 07102, United States.
ACS Omega. 2024 Aug 30;9(37):38557-38568. doi: 10.1021/acsomega.4c02948. eCollection 2024 Sep 17.
Quercetin possesses high biological properties but low bioavailability, poor solubility, and rapid body clearance. Its structural modification is imperative for enhanced applications. Herein, we demonstrate the catalytic and antimicrobial characteristics of shape-dependent (cuboidal and peanuts) platinum nanoparticles. Modified quercetin, 4-QP, was employed as the reducing and stabilizing agent for the aqueous synthesis of PtNPs without extraneous reagents. Monodispersed platinum nanocubes (C-PtNPs) and nanopeanuts (P-PtNPs) were produced by reacting 4-QP and Pt ions in the ratios of 3:1 and 1:1, respectively. TEM characterization confirmed the formation of Pt nanocubes and Pt nanopeanuts, with their corresponding sizes of 39.1 ± 0.20 and 45.1 ± 0.24 nm. The shape-dependency of PtNPs on the nosocomial-causing bacteria, ATCC 8090 () was determined by the Agar well-diffusion assay. Under the same particle size and dose treatments, C-PtNPs and P-PtNPs exhibited 16.28 ± 0.10 and 4.50 ± 0.15 mm zones of inhibition with minimum inhibitory concentrations of 25 and 45 μg/mL, respectively. SEM analysis of C-PtNPs treated showed a damaged cell membrane and confirmed contact-killing as the antibacterial mechanism. The catalytic conversion of 4-nitrophenol (4-NP) to 4-amino phenol (4-AP) was tested using a shape-dependent PtNPs catalyst in the presence of sodium borohydride. The conversion rates () of C-PtNPs and P-PtNPs in wastewater samples from New Jersey were 0.0108 and 0.00607 s, respectively.
槲皮素具有很高的生物学特性，但生物利用度低、溶解度差且在体内清除迅速。对其进行结构修饰对于增强其应用至关重要。在此，我们展示了形状依赖性（立方体形和花生形）铂纳米颗粒的催化和抗菌特性。改性槲皮素4-QP被用作水相合成铂纳米颗粒的还原剂和稳定剂，无需额外试剂。通过分别以3:1和1:1的比例使4-QP与铂离子反应，制备出了单分散的铂纳米立方体（C-PtNPs）和纳米花生（P-PtNPs）。透射电子显微镜（TEM）表征证实了铂纳米立方体和铂纳米花生的形成，其相应尺寸分别为39.1±0.20和45.1±0.24纳米。通过琼脂扩散法测定了铂纳米颗粒对医院感染病原菌ATCC 8090（）的形状依赖性。在相同粒径和剂量处理下，C-PtNPs和P-PtNPs的抑菌圈直径分别为16.28±0.10和4.50±0.15毫米，最低抑菌浓度分别为25和45微克/毫升。对经C-PtNPs处理的进行扫描电子显微镜（SEM）分析，结果显示细胞膜受损，证实接触杀灭为抗菌机制。在硼氢化钠存在的情况下，使用形状依赖性铂纳米颗粒催化剂测试了4-硝基苯酚（4-NP）向4-氨基苯酚（4-AP）的催化转化。新泽西州废水样品中C-PtNPs和P-PtNPs的转化率分别为0.0108和0.00607秒⁻¹。
