State Key Laboratory of Chemical Resource Engineering, Beijing University of Chemical Technology, No. 15 East Road of North Third Ring, Chao Yang District, Beijing 100029, China.
State Key Laboratory of Chemical Resource Engineering, Beijing University of Chemical Technology, No. 15 East Road of North Third Ring, Chao Yang District, Beijing 100029, China.
J Photochem Photobiol B. 2017 Aug;173:368-375. doi: 10.1016/j.jphotobiol.2017.06.018. Epub 2017 Jun 16.
Platinum based drugs are considered as effective agents against various types of carcinoma; however, the severe toxicity associated with the chemically prepared platinum complexes limit their practical applications. Similarly, water pollution caused by various organic moieties is another serious health problem worldwide. Hence, an intense need exists to develop new, effective and biocompatible materials with catalytic and biomedical applications. In the present contribution, we prepared platinum nanoparticles (PtNPs) by a green route using phytochemicals as a source of reducing and stabilizing agents. Well dispersed and crystalline PtNPs of spherical shapes were prepared and characterized. The bio-fabricated PtNPs were used as catalyst and anticancer agents. Catalytic performance of the PtNPs showed that 84% of the methylene blue can be reduced in 32min under visible light irradiation (K=0.078min). Similarly the catalytic conversion of 4-nitrophenol to 4-aminophenol was achieved in <20min (K=0.124min). The in vitro anticancer study revealed that biogenic PtNPs are the efficient nano-agents possessing strong anticancer activity against the lungs cancer cells line (A549). Interestingly, the as prepared PtNPs were well tolerated by normal human cells, and therefore, could be effective and biocompatible agents in the treatment of different cancer cells.
基于铂的药物被认为是对抗各种类型癌的有效药物；然而，与化学制备的铂配合物相关的严重毒性限制了它们的实际应用。同样，各种有机基团引起的水污染也是全世界另一个严重的健康问题。因此，迫切需要开发具有催化和生物医学应用的新型、有效和生物相容性的材料。在本研究中，我们使用植物化学物质作为还原和稳定试剂，通过绿色途径制备了铂纳米颗粒（PtNPs）。制备并表征了分散性好且结晶的球形 PtNPs。所制备的生物合成 PtNPs 可用作催化剂和抗癌剂。PtNPs 的催化性能表明，在可见光照射下，84%的亚甲蓝可以在 32 分钟内被还原（K=0.078min）。同样，4-硝基苯酚在<20 分钟内转化为 4-氨基酚（K=0.124min）。体外抗癌研究表明，生物合成的 PtNPs 是有效的纳米药物，对肺癌细胞系（A549）具有很强的抗癌活性。有趣的是，所制备的 PtNPs 被正常人类细胞很好地耐受，因此，可作为治疗不同癌细胞的有效和生物相容性药物。
