Kwon Jihyun, Ko Na Yeong, Lim Ji Won
Chem-Bio Center, Agency for Defense Development, Advanced Defense Science & Technology Research Institute, Daejeon 34186, Republic of Korea.
ACS Omega. 2024 Aug 17;9(37):38583-38590. doi: 10.1021/acsomega.4c04000. eCollection 2024 Sep 17.
The persistent threat posed by chemical warfare agents (CWAs) necessitates the development of efficient and safe methods for their neutralization. In this study, we investigated the continuous neutralization of CWAs and their simulants using flow chemistry, which combines the benefits of safety, precise control over reaction parameters, and scalability. We focused on the integration of continuous-flow reactors to achieve controlled and rapid neutralization, thus addressing challenges such as the need for rapid reaction kinetics and the establishment of robust pathways for neutralization. Because the flow-chemistry approach can contribute significantly to the development of neutralization technologies for CWAs, we performed a thorough characterization in terms of reaction kinetics and neutralized product identification. The results demonstrated that the proposed continuous-flow-type neutralization reaction was faster and more efficient than batch-type neutralization reactions. Furthermore, in the early stages of the neutralization reaction, flow-type neutralization not only required less neutralizing agent than batch-type neutralization but was also faster. Thus, the chemical neutralization process proposed in this study can be used as a pragmatic foundation for developing demilitarization methods for CWAs.
化学战剂（CWAs）构成的持续威胁使得开发高效且安全的中和方法成为必要。在本研究中，我们利用流动化学研究了化学战剂及其模拟物的连续中和过程，流动化学兼具安全、对反应参数精确控制以及可扩展性等优点。我们着重于连续流反应器的整合，以实现可控且快速的中和，从而应对诸如快速反应动力学需求以及建立稳健中和途径等挑战。由于流动化学方法能够对化学战剂中和技术的发展做出重大贡献，我们在反应动力学和中和产物鉴定方面进行了全面表征。结果表明，所提出的连续流型中和反应比间歇型中和反应更快且更高效。此外，在中和反应的早期阶段，流动型中和不仅比间歇型中和所需的中和剂更少，而且速度更快。因此，本研究中提出的化学中和过程可作为开发化学战剂非军事化方法的实用基础。
