Ceulemans D L, Hoppenbrouwers M L, Gelders Y G, Reyntjens A J
Pharmacopsychiatry. 1985 Sep;18(5):303-5. doi: 10.1055/s-2007-1017385.
A double-blind study was performed in 83 patients with generalized anxiety disorder comparing daily doses of 5 and 10 mg ritanserin (a selective antagonist of serotonine S2 receptors) versus placebo and 4 mg lorazepam as reference drug. Patients treated with 10 mg ritanserin or 4 mg lorazepam improved significantly better (p less than 0.05) after two weeks than those treated with placebo. On the other hand a daily dose of 5 mg ritanserin appeared to be not superior to placebo. Patients treated with 4 mg lorazepam complained significantly more about sedation and dizziness than patients treated with 10 mg ritanserin (p less than 0.05).
对83例广泛性焦虑症患者进行了一项双盲研究，比较每日5毫克和10毫克利坦色林（一种5-羟色胺S2受体选择性拮抗剂）与安慰剂以及作为对照药物的4毫克劳拉西泮的疗效。与接受安慰剂治疗的患者相比，接受10毫克利坦色林或4毫克劳拉西泮治疗的患者在两周后改善显著更好（p小于0.05）。另一方面，每日5毫克利坦色林似乎并不优于安慰剂。与接受10毫克利坦色林治疗的患者相比，接受4毫克劳拉西泮治疗的患者出现镇静和头晕的抱怨明显更多（p小于0.05）。
