在危重症儿童和成人中，肺部是肺炎的反向生物标志物。 - Suppr

Pulmonary Is an Inverse Biomarker of Pneumonia in Critically Ill Children and Adults.

作者信息

Lydon Emily C, Phan Hoang Van, Mick Eran, Spottiswoode Natasha, Calfee Carolyn S, Mourani Peter M, Langelier Charles R

机构信息

Division of Infectious Diseases and.

Division of Pulmonary and Critical Care Medicine, Cardiovascular Research Institute, University of California, San Francisco, San Francisco, California.

出版信息

Am J Respir Crit Care Med. 2024 Dec 15;210(12):1480-1483. doi: 10.1164/rccm.202403-0516RL.

DOI:10.1164/rccm.202403-0516RL

PMID:39312201

Abstract

摘要

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Pulmonary Is an Inverse Biomarker of Pneumonia in Critically Ill Children and Adults.在危重症儿童和成人中，肺部是肺炎的反向生物标志物。

Am J Respir Crit Care Med. 2024 Dec 15;210(12):1480-1483. doi: 10.1164/rccm.202403-0516RL.

Integrating a host transcriptomic biomarker with a large language model for diagnosis of lower respiratory tract infection.整合宿主转录组生物标志物与大语言模型用于诊断下呼吸道感染。

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Oral hygiene care for critically ill patients to prevent ventilator-associated pneumonia.危重症患者的口腔卫生护理以预防呼吸机相关性肺炎。

Cochrane Database Syst Rev. 2016 Oct 25;10(10):CD008367. doi: 10.1002/14651858.CD008367.pub3.

Short-course versus prolonged-course antibiotic therapy for hospital-acquired pneumonia in critically ill adults.重症成年患者医院获得性肺炎的短疗程与长疗程抗生素治疗

Cochrane Database Syst Rev. 2015 Aug 24;2015(8):CD007577. doi: 10.1002/14651858.CD007577.pub3.

Post-pyloric versus gastric tube feeding for preventing pneumonia and improving nutritional outcomes in critically ill adults.幽门后喂养与胃管喂养对预防重症成年患者肺炎及改善营养结局的比较

Cochrane Database Syst Rev. 2015 Aug 4;2015(8):CD008875. doi: 10.1002/14651858.CD008875.pub2.

A Descriptive Study on Clinical Pulmonary Infection Score (CPIS) in Early Identification of Hospital-Acquired Pneumonia (HAP) Among Critically Ill Patients in a Tertiary Care Teaching Hospital.三级护理教学医院重症患者医院获得性肺炎（HAP）早期识别中临床肺部感染评分（CPIS）的描述性研究

Cureus. 2025 Jul 27;17(7):e88841. doi: 10.7759/cureus.88841. eCollection 2025 Jul.

Oral hygiene care for critically ill patients to prevent ventilator-associated pneumonia.重症患者的口腔卫生护理以预防呼吸机相关性肺炎。

Cochrane Database Syst Rev. 2013 Aug 13(8):CD008367. doi: 10.1002/14651858.CD008367.pub2.

Nutritional support for critically ill children.危重症儿童的营养支持

Cochrane Database Syst Rev. 2016 May 27;2016(5):CD005144. doi: 10.1002/14651858.CD005144.pub3.

Early versus late tracheostomy in critically ill COVID-19 patients.危重症 COVID-19 患者的早期与晚期气管切开术。

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Diagnosis and treatment of invasive pulmonary aspergillosis in critically ill intensive care patients: executive summary of the German national guideline (AWMF 113-005).重症监护病房危重症患者侵袭性肺曲霉病的诊断与治疗：德国国家指南（AWMF 113 - 005）执行摘要

Infection. 2025 Jun 4. doi: 10.1007/s15010-025-02572-2.

引用本文的文献

medRxiv. 2025 Apr 3:2024.08.28.24312732. doi: 10.1101/2024.08.28.24312732.

本文引用的文献

Integrated host/microbe metagenomics enables accurate lower respiratory tract infection diagnosis in critically ill children.整合宿主/微生物宏基因组学可实现重症患儿下呼吸道感染的准确诊断。

J Clin Invest. 2023 Apr 3;133(7):e165904. doi: 10.1172/JCI165904.

A shift in lung macrophage composition is associated with COVID-19 severity and recovery.肺巨噬细胞组成的变化与 COVID-19 的严重程度和恢复有关。

Sci Transl Med. 2022 Sep 14;14(662):eabn5168. doi: 10.1126/scitranslmed.abn5168.

Molecular Profiling of Innate Immune Response Mechanisms in Ventilator-associated Pneumonia.呼吸机相关性肺炎中固有免疫反应机制的分子剖析

Mol Cell Proteomics. 2020 Oct;19(10):1688-1705. doi: 10.1074/mcp.RA120.002207. Epub 2020 Jul 24.

Single-cell landscape of bronchoalveolar immune cells in patients with COVID-19.COVID-19 患者支气管肺泡免疫细胞的单细胞景观。

Nat Med. 2020 Jun;26(6):842-844. doi: 10.1038/s41591-020-0901-9. Epub 2020 May 12.

Reduced airway levels of fatty-acid binding protein 4 in COPD: relationship with airway infection and disease severity.COPD 患者气道中脂肪酸结合蛋白 4 水平降低：与气道感染和疾病严重程度的关系。

Respir Res. 2020 Jan 13;21(1):21. doi: 10.1186/s12931-020-1278-5.

Integrating host response and unbiased microbe detection for lower respiratory tract infection diagnosis in critically ill adults.整合宿主反应和非偏倚微生物检测以诊断危重症成人下呼吸道感染。

Proc Natl Acad Sci U S A. 2018 Dec 26;115(52):E12353-E12362. doi: 10.1073/pnas.1809700115. Epub 2018 Nov 27.

Procalcitonin as a Marker of Etiology in Adults Hospitalized With Community-Acquired Pneumonia.降钙素原作为成人社区获得性肺炎病因标志物的研究。

Clin Infect Dis. 2017 Jul 15;65(2):183-190. doi: 10.1093/cid/cix317.

Community-acquired pneumonia requiring hospitalization among U.S. children.美国儿童中需要住院治疗的社区获得性肺炎。

N Engl J Med. 2015 Feb 26;372(9):835-45. doi: 10.1056/NEJMoa1405870.

Fatty Acid-Binding Protein 4 (FABP4): Pathophysiological Insights and Potent Clinical Biomarker of Metabolic and Cardiovascular Diseases.脂肪酸结合蛋白4（FABP4）：代谢性和心血管疾病的病理生理学见解及强效临床生物标志物

Clin Med Insights Cardiol. 2015 Feb 2;8(Suppl 3):23-33. doi: 10.4137/CMC.S17067. eCollection 2014.

Diagnostic value of C reactive protein in infections of the lower respiratory tract: systematic review.C反应蛋白在下呼吸道感染中的诊断价值：系统评价

BMJ. 2005 Jul 2;331(7507):26. doi: 10.1136/bmj.38483.478183.EB. Epub 2005 Jun 24.

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Pulmonary Is an Inverse Biomarker of Pneumonia in Critically Ill Children and Adults.

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