Department of Ophthalmology, The Second People's Hospital of Foshan, Foshan 528000, China.
Department of Ophthalmology, The Second People's Hospital of Foshan, Foshan 528000, China.
Photodiagnosis Photodyn Ther. 2024 Oct;49:104339. doi: 10.1016/j.pdpdt.2024.104339. Epub 2024 Sep 21.
The purpose of this study was to investigate the vessel density (VD) of the macular superficial capillary plexus (SCP) and its associated factors in healthy subjects.
This prospective, cross-sectional study enrolled healthy Chinese volunteers. The optical coherence tomography angiography (OCTA) was used to measure the superficial VD in macula. A generalized estimation equation (GEE) model was used to analyze the ocular and systemic associated factors.
A total of 516 eyes of 262 healthy subjects were included (mean age 38.59 ± 21.03 years). The total VD of macular SCP was 16.85 ± 2.28 mm. The VD in the inner ring and outer ring were significantly higher than that in the central ring, with the density being highest in nasal quadrant and lowest in the superior quadrant. After adjusting the ocular and systemic factors, age (β=-0.0085, P = 0.0122) and SSI (β=1.3261, P < 0.001) were significantly associated with total VD of the macular SCP.
Among the healthy Chinese subjects included in the study, the mean total VD of macular SCP was 16.85 ± 2.28mm. The macular superficial capillary density was positively associated with age and SSI. Further studies are still required to better understand the change of macular VD in aging and other pathological conditions.
本研究旨在探讨健康受试者黄斑浅层毛细血管丛（SCP）的血管密度（VD）及其相关因素。
这是一项前瞻性、横断面研究，纳入了健康的中国志愿者。使用光相干断层扫描血管造影（OCTA）测量黄斑区浅层 VD。采用广义估计方程（GEE）模型分析眼部和全身相关因素。
共纳入 262 名健康受试者的 516 只眼（平均年龄 38.59±21.03 岁）。黄斑 SCP 的总 VD 为 16.85±2.28mm。内环和外环的 VD 明显高于中环，密度以鼻象限最高，上象限最低。调整眼部和全身因素后，年龄（β=-0.0085，P=0.0122）和 SSI（β=1.3261，P<0.001）与黄斑 SCP 的总 VD 显著相关。
在纳入本研究的健康中国受试者中，黄斑 SCP 的平均总 VD 为 16.85±2.28mm。黄斑浅层毛细血管密度与年龄和 SSI 呈正相关。仍需要进一步研究以更好地了解衰老和其他病理状态下黄斑 VD 的变化。
