Placzek Marysia, Chinnaiya Kavitha, Kim Dong Won, Blackshaw Seth
School of Biosciences, University of Sheffield, Sheffield, UK.
Bateson Centre, University of Sheffield, Sheffield, UK.
Nat Rev Endocrinol. 2025 Feb;21(2):118-130. doi: 10.1038/s41574-024-01036-1. Epub 2024 Sep 23.
The tuberal hypothalamus regulates a range of crucial physiological processes, including energy homeostasis and metabolism. In this Review, we explore the intricate molecular mechanisms and signalling pathways that control the development of the tuberal hypothalamus, focusing on aspects that shape metabolic outcomes. Major developmental events are discussed in the context of their effect on the establishment of both functional hypothalamic neuronal circuits and brain-body interfaces that are pivotal to the control of metabolism. Emerging evidence indicates that aberrations in molecular pathways during tuberal hypothalamic development contribute to metabolic dysregulation. Understanding the molecular underpinnings of tuberal hypothalamic development provides a comprehensive view of neurodevelopmental processes and offers a promising avenue for future targeted interventions to prevent and treat metabolic disorders.
结节性下丘脑调节一系列关键的生理过程，包括能量平衡和代谢。在本综述中，我们探讨了控制结节性下丘脑发育的复杂分子机制和信号通路，重点关注影响代谢结果的方面。主要发育事件将在其对功能性下丘脑神经元回路和对代谢控制至关重要的脑-体界面建立的影响背景下进行讨论。新出现的证据表明，结节性下丘脑发育过程中分子途径的异常导致代谢失调。了解结节性下丘脑发育的分子基础，能全面了解神经发育过程，并为未来预防和治疗代谢紊乱的靶向干预提供了一条有前景的途径。
