Ayik Türk Merve, Polat Gülru, Özdemir Özer, Türk Yunus, Kömürcüoğlu Berna
Department of Pulmonology, İzmir Bozyaka Training and Research Hospital, Bahar, Saim Çıkrıkçı Street No:59, 35170, Izmir, Turkey.
Department of Pulmonology, Dr. Suat Seren Chest Diseases and Surgery Training and Research Hospital, Gaziler St. No: 331, 35110, Izmir, Turkey.
Updates Surg. 2024 Dec;76(8):2885-2892. doi: 10.1007/s13304-024-01985-2. Epub 2024 Sep 23.
Malignant pleural effusion (MPE) is a complication of malignancy. Treatment of MPE is based on predicted outcome. The aim of this study was to compare the performance characteristics of LENT, PROMISE, RECLS, AL and pNLR scores for prediction of mortality in lung cancer patients who have MPE. Patients who were diagnosed with MPE that was associated with underlying lung cancer between January 2010 and December 2019 were included and analyzed retrospectively in a single center. Outcomes considered were 30-day, 6 months, and 1-year mortality. A total of 180 patients were examined. For 30-day mortality, the areas under the ROC curves (AUC) (95% CI) were: LENT 0.83 (0.76-0.87), RECLS 0.71 (0.63-0.77), and PROMISE 0.70 (0.17-0.38). For 6-month and 1-year mortality the order of these AUCs was similar. Cox regression showed that none of the scores were significantly associated with 30-day mortality, but LENT and RECLS were significantly associated with 6-month and 1-year mortality. Comparison of - 2log likelihood ratios showed that LENT score was more, strongly associated with 6-month mortality than PROMISE (p = 0.001) or RECLS (p = 0.02). LENT score was also more strongly associated with 1-year mortality than PROMISE (p = 0.001) but there was no difference between LENT and RECLS score (p = 0.64). We observed that the LENT score was more predictive than the other scores in mortality in patients who have lung cancer and MPE. The LENT and RECLS scores have similar performance characteristics for prediction of 1-year mortality in these patients.
恶性胸腔积液（MPE）是恶性肿瘤的一种并发症。MPE的治疗基于预测结果。本研究的目的是比较LENT、PROMISE、RECLS、AL和pNLR评分在预测患有MPE的肺癌患者死亡率方面的性能特征。纳入2010年1月至2019年12月期间被诊断为与潜在肺癌相关的MPE患者，并在单一中心进行回顾性分析。所考虑的结局为30天、6个月和1年死亡率。共检查了180例患者。对于30天死亡率，ROC曲线下面积（AUC）（95%CI）分别为：LENT 0.83（0.76 - 0.87）、RECLS 0.71（0.63 - 0.77）和PROMISE 0.70（0.17 - 0.38）。对于6个月和1年死亡率，这些AUC的顺序相似。Cox回归显示，这些评分均与30天死亡率无显著相关性，但LENT和RECLS与6个月和1年死亡率显著相关。-2对数似然比的比较显示，LENT评分与6个月死亡率的相关性比PROMISE（p = 0.001）或RECLS（p = 0.02）更强。LENT评分与1年死亡率的相关性也比PROMISE更强（p = 0.001），但LENT和RECLS评分之间无差异（p = 0.64）。我们观察到，在患有肺癌和MPE的患者中，LENT评分在预测死亡率方面比其他评分更具预测性。在预测这些患者的1年死亡率方面，LENT和RECLS评分具有相似的性能特征。
