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一种新型内镜下环状软骨前肋骨移植术:动物模型的可行性研究

A Novel Endoscopic Anterior Cricoid Rib Grafting: A Feasibility Study in An Animal Model.

作者信息

Aldriweesh Bshair, Almutairi Nasser, Alshareef Waleed, Sindi Abdullah, Alammar Ahmed

机构信息

Department of Otolaryngology-Head and Neck Surgery King Saud University Medical City, College of Medicine, King Saud University Riyadh Kingdom of Saudi Arabia.

Present address: Department of Otolaryngology-Head and Neck Surgery Maternity and Children Hospital Makkah Saudi Arabia.

出版信息

OTO Open. 2024 Sep 23;8(3):e70012. doi: 10.1002/oto2.70012. eCollection 2024 Jul-Sep.

DOI:10.1002/oto2.70012
PMID:39314529
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC11418163/
Abstract

OBJECTIVE

The objective of our study was to document the feasibility of a novel endoscopic anterior cricoid split and rib grafting technique in a goat airway model.

STUDY DESIGN

Feasibility pilot animal study.

SETTING

Animal surgical laboratory at a tertiary hospital and research center.

METHODS

Three Ardhi goats were utilized. After harvesting and shaping the rib graft, 2 sutures were inserted transversely into the graft. An endoscopic midline anterior cricoid split was performed and extended down through the first tracheal ring, followed by a balloon dilation of the site. Next, the 2 lower and upper graft suture ends were sequentially passed as endo-extra laryngeal sutures and tied on the anterior neck skin. Laryngeal stent was utilized in 1 goat following graft placement.

RESULTS

The surgery was successful in all included animals and bronchoscopy performed 7 days after surgery, revealed that the anterior graft was in good position. One goat developed surgical site infection leading to partial graft resorption.

CONCLUSION

This study demonstrated the feasibility of this novel procedure which is potentially useful for patients who are candidates for a single-stage reconstruction. Future studies should investigate the safety and validity of this technique in a model with subglottic stenosis.

LEVEL OF EVIDENCE

NA.

摘要

目的

本研究的目的是在山羊气道模型中记录一种新型内镜下环状软骨前部劈开及肋骨移植技术的可行性。

研究设计

可行性初步动物研究。

研究地点

一家三级医院和研究中心的动物外科实验室。

方法

使用3只阿尔迪山羊。在获取并塑形肋骨移植物后,将2根缝线横向插入移植物。进行内镜下环状软骨前部中线劈开,并向下延伸至第一气管环,随后对该部位进行球囊扩张。接下来,将移植物上下两端的缝线依次作为喉内外缝线穿过,并在前颈部皮肤打结。1只山羊在植入移植物后使用了喉支架。

结果

所有纳入研究的动物手术均成功,术后7天进行的支气管镜检查显示前部移植物位置良好。1只山羊发生手术部位感染,导致部分移植物吸收。

结论

本研究证明了这种新手术的可行性,该手术对适合一期重建的患者可能有用。未来的研究应在声门下狭窄模型中研究该技术的安全性和有效性。

证据级别

无。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/4ed3/11418163/98e4492d04d5/OTO2-8-e70012-g005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/4ed3/11418163/12c8dff7de55/OTO2-8-e70012-g004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/4ed3/11418163/8489a3113755/OTO2-8-e70012-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/4ed3/11418163/66e6c258bc61/OTO2-8-e70012-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/4ed3/11418163/35bdf7e23816/OTO2-8-e70012-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/4ed3/11418163/98e4492d04d5/OTO2-8-e70012-g005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/4ed3/11418163/12c8dff7de55/OTO2-8-e70012-g004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/4ed3/11418163/8489a3113755/OTO2-8-e70012-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/4ed3/11418163/66e6c258bc61/OTO2-8-e70012-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/4ed3/11418163/35bdf7e23816/OTO2-8-e70012-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/4ed3/11418163/98e4492d04d5/OTO2-8-e70012-g005.jpg

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本文引用的文献

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Laryngoscope. 2022 Jan;132(1):212-214. doi: 10.1002/lary.29744. Epub 2021 Aug 6.
2
Validation of Animal Models for Simulation Training in Pediatric Laryngotracheal Reconstruction.小儿喉气管重建模拟训练动物模型的验证
Ann Otol Rhinol Laryngol. 2020 Jan;129(1):46-54. doi: 10.1177/0003489419870820. Epub 2019 Aug 30.
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Lamb larynx model for training in endoscopic and CO laser-assisted surgeries for benign laryngotracheal obstructions.
用于良性喉气管阻塞的内镜手术和CO激光辅助手术训练的羊喉模型。
Eur Arch Otorhinolaryngol. 2018 Aug;275(8):2061-2069. doi: 10.1007/s00405-018-5011-7. Epub 2018 Jun 4.
4
Systematic review for surgical treatment of adult and adolescent laryngotracheal stenosis.成人及青少年喉气管狭窄手术治疗的系统评价
Laryngoscope. 2017 Jan;127(1):191-198. doi: 10.1002/lary.26151. Epub 2016 Oct 21.
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Endoscopic posterior cricoid split with costal cartilage graft: A fifteen-year experience.内镜下环状软骨后裂开术联合肋软骨移植:15年经验
Laryngoscope. 2017 Jan;127(1):252-257. doi: 10.1002/lary.26200. Epub 2016 Jul 28.
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Endoscopic anterior cricoid split with balloon dilation in infants with failed extubation.内镜下环状软骨前部切开联合球囊扩张在拔管失败婴儿中的应用。
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Endoscopic anterior cricoid split and balloon dilation in pediatric subglottic stenosis.小儿声门下狭窄的内镜下环状软骨前部劈开及球囊扩张术
Int J Pediatr Otorhinolaryngol. 2010 Dec;74(12):1409-14. doi: 10.1016/j.ijporl.2010.09.020. Epub 2010 Oct 25.
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