Wu Tao, Yang Yan, Su He, Gu Yuanhui, Ma Quanming, Zhang Yan
Key Laboratory of Molecular Diagnostics and Precision Medicine for Surgical Oncology in Gansu province, Gansu Provincial Hospital, 730000 Lanzhou, PR China.
Key Laboratory of Molecular Diagnostics and Precision Medicine for Surgical Oncology in Gansu province, Gansu Provincial Hospital, 730000 Lanzhou, PR China; The First School of Clinical Medicine, Lanzhou University, 730000 Lanzhou, PR China.
Colloids Surf B Biointerfaces. 2022 Nov;219:112837. doi: 10.1016/j.colsurfb.2022.112837. Epub 2022 Sep 10.
Cholestasis of the indwelling biliary stents usually leads to stone recurrence after endoscopic retrograde cholangio pancreatoraphy (ERCP). Biliary stents, including metallic and none-degradable plastic stents are widely used in clinical settings due to their many excellent properties. However, conventional biliary stents still suffer from poor antibacterial activity and anti-bile-adhesion, which lead to injured, local fibroblasts proliferating. Currently, various coatings for biliary stents have been prepared to meet the clinical demands. In this review, we start by summarizing and discussing classifications of biliary stents and antibacterial/antibiofilm mechanism. Then, the latest advances about developing antibacterial and antibiofilm coatings for improving the properties of biliary stents are reviewed and discussed in detail. Lastly, we list several possible directions for future development of biliary stents coatings and biliary stent, such as anti-bile-adhesion coating, multifunctional coating, drug-eluting biodegradable biliary stents and 3D printed biliary stents.
留置胆管支架的胆汁淤积通常会导致内镜逆行胰胆管造影术（ERCP）后结石复发。包括金属和不可降解塑料支架在内的胆管支架因其诸多优异性能而在临床中广泛应用。然而，传统胆管支架仍存在抗菌活性差和抗胆汁粘附性差的问题，这会导致局部成纤维细胞受损增殖。目前，已制备了各种胆管支架涂层以满足临床需求。在本综述中，我们首先总结并讨论胆管支架的分类以及抗菌/抗生物膜机制。然后，详细综述并讨论了用于改善胆管支架性能的抗菌和抗生物膜涂层的最新进展。最后，我们列出了胆管支架涂层和胆管支架未来发展的几个可能方向，如抗胆汁粘附涂层、多功能涂层、药物洗脱可降解胆管支架和3D打印胆管支架。
