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基于网络药理学发现抽动秽语综合征的关键生物标志物

Discovery of key biomarkers in tourette syndrome by network pharmacology.

作者信息

Zhao Jiali, Bai Xiaohong

机构信息

Liaoning University of Traditional Chinese Medicine, Shenyang, China.

Harbin Hospital of Traditional Chinese Medicine, Harbin, Heilongjiang, China.

出版信息

Front Pharmacol. 2024 Sep 10;15:1397203. doi: 10.3389/fphar.2024.1397203. eCollection 2024.

DOI:10.3389/fphar.2024.1397203
PMID:39318779
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC11420008/
Abstract

BACKGROUND

Yangxue Xifeng Decoction (YXD) has been utilized in clinical settings for the treatment of Tourette Syndrome (TS). However, the action mechanism of YXD needs further research.

METHODS

The ingredients and targets of YXD were identified via database searches and then constructed an active ingredient-target network using Cytoscape. Pathway enrichment analysis was performed via Gene Ontology (GO) and Kyoto Encyclopedia of Genes and Genomes (KEGG). The core genes were determined by LASSO regression and SVM algorithm. Additionally, we analyzed the immune infiltration. The signaling pathways associated with core genes were investigated through KEGG and GO. We predicted the transcription factors using "RcisTarge".

RESULTS

127 active ingredients of YXD and 255 targets were obtained. TNF and the IL-17 signaling pathway were the main pathways. and were screened out as core genes, which were associated with the immune infiltration. The signaling pathways involved in and were enriched. Furthermore, remarkable correlation was found between and levels and other TS-related genes such as and .

CONCLUSION

and and the signaling pathways are associated with TS. YXD exerts its therapeutic TS through multi-component and multi-targets including immune infiltration.

摘要

背景

养血熄风汤（YXD）已被用于临床治疗抽动秽语综合征（TS）。然而，YXD的作用机制需要进一步研究。

方法

通过数据库检索确定YXD的成分和靶点，然后使用Cytoscape构建活性成分-靶点网络。通过基因本体论（GO）和京都基因与基因组百科全书（KEGG）进行通路富集分析。通过LASSO回归和支持向量机（SVM）算法确定核心基因。此外，我们分析了免疫浸润情况。通过KEGG和GO研究与核心基因相关的信号通路。我们使用“RcisTarge”预测转录因子。

结果

获得了YXD的127种活性成分和255个靶点。肿瘤坏死因子（TNF）和白细胞介素-17（IL-17）信号通路是主要通路。筛选出 和 作为核心基因，它们与免疫浸润相关。涉及 和 的信号通路得到富集。此外，发现 和 水平与其他TS相关基因如 和 之间存在显著相关性。

结论

和 以及相关信号通路与TS相关。YXD通过包括免疫浸润在内的多成分、多靶点发挥治疗TS的作用。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/f369/11420008/3a259d2ded60/fphar-15-1397203-g008.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/f369/11420008/3126184ff263/fphar-15-1397203-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/f369/11420008/36e723f375ef/fphar-15-1397203-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/f369/11420008/3526f4b50c78/fphar-15-1397203-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/f369/11420008/b2450f0e0d73/fphar-15-1397203-g004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/f369/11420008/29990f1eb487/fphar-15-1397203-g005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/f369/11420008/7cf8aa305634/fphar-15-1397203-g006.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/f369/11420008/e2fe78745eee/fphar-15-1397203-g007.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/f369/11420008/3a259d2ded60/fphar-15-1397203-g008.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/f369/11420008/3126184ff263/fphar-15-1397203-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/f369/11420008/36e723f375ef/fphar-15-1397203-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/f369/11420008/3526f4b50c78/fphar-15-1397203-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/f369/11420008/b2450f0e0d73/fphar-15-1397203-g004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/f369/11420008/29990f1eb487/fphar-15-1397203-g005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/f369/11420008/7cf8aa305634/fphar-15-1397203-g006.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/f369/11420008/e2fe78745eee/fphar-15-1397203-g007.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/f369/11420008/3a259d2ded60/fphar-15-1397203-g008.jpg

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