儿童哮喘对精神疾病的因果效应：一项双向孟德尔随机化研究。
Causal effects of pediatric asthma on psychiatric disorders: a bidirectional Mendelian randomization study.
作者信息
Jiang Zhengxing, Long Xiao, Die Xiaohong, Hou Jinping, Wang Yujie, Wang Yi, Feng Wei
机构信息
Department of General and Neonatal Surgery, Children's Hospital of Chongqing Medical University, National Clinical Research Center for Child Health and Disorders, Ministry o Education Key Laboratory of Child Development and Disorders, Chongqing Key Laboratory of Structural Birth Defect and Reconstruction, Chongqing, China.
Department of Respiratory Medicine, Children's Hospital of Chongqing Medical University, National Clinical Research Center for Child Health and Disorders, Ministry o Education Key Laboratory of Child Development and Disorders, Chongqing Key Laboratory of Pediatric Metabolism and Inflammatory Diseases, Chongqing, China, Key Laboratory of Children's Important Organ Development and Diseases of Chongqing Municipal Health Commission, Chongqing, China.
出版信息
J Asthma. 2025 Mar;62(3):445-455. doi: 10.1080/02770903.2024.2409418. Epub 2024 Oct 3.
BACKGROUND
Previous studies have suggested a potential link between pediatric asthma and psychiatric disorders. However, the causal relationship between pediatric asthma and psychiatric disorders is unclear. Therefore, we used Mendelian randomization to explore causal relationships between pediatric asthma and depression, anxiety disorders, and attention deficit and hyperactivity disorder (ADHD).
METHODS
Genome-wide association studies (GWAS) meta-analyses with the largest possible sample size and independent individuals from European ancestry were selected. The genetic data for depression and anxiety are from FinnGen consortium, while the genetic data for ADHD is from the Psychiatric Genomics Consortium. Inverse variance weighted (IVW) was the main analysis method. The heterogeneity of the instrumental variables (IVs) was assessed using IVW, and the horizontal pleiotropy of the IVs was assessed using MR-Egger.
RESULT
The IVW results showed a significant causal relationship between pediatric asthma and depression (OR = 1.08, 95% CI = 1.02-1.15; = 0.013). However, there is no evidence to suggest a causal relationship between pediatric asthma, anxiety, and ADHD. Reverse MR suggests a significant causal relationship (OR = 1.27, 95% CI [1.14-1.41], = 9.64E - 06) between ADHD and pediatric asthma using the IVW method.
CONCLUSIONS
Our findings suggest a causal relationship between pediatric asthma and an increased risk of depression. Additionally, we found that ADHD is significantly associated with a higher risk of pediatric asthma.
背景
既往研究提示儿童哮喘与精神障碍之间可能存在联系。然而，儿童哮喘与精神障碍之间的因果关系尚不清楚。因此，我们采用孟德尔随机化方法来探讨儿童哮喘与抑郁症、焦虑症以及注意力缺陷多动障碍（ADHD）之间的因果关系。
方法
选择样本量尽可能大且为欧洲血统独立个体的全基因组关联研究（GWAS）荟萃分析。抑郁症和焦虑症的遗传数据来自芬兰基因组联盟，而ADHD的遗传数据来自精神基因组学联盟。逆方差加权（IVW）是主要分析方法。使用IVW评估工具变量（IVs）的异质性，使用MR-Egger评估IVs的水平多效性。
结果
IVW结果显示儿童哮喘与抑郁症之间存在显著因果关系（OR = 1.08，95%CI = 1.02 - 1.15；P = 0.013）。然而，没有证据表明儿童哮喘与焦虑症和ADHD之间存在因果关系。反向MR提示使用IVW方法时ADHD与儿童哮喘之间存在显著因果关系（OR = 1.27，95%CI [1.14 - 1.41]，P = 9.64E - 06）。
结论
我们的研究结果提示儿童哮喘与抑郁症风险增加之间存在因果关系。此外，我们发现ADHD与儿童哮喘风险较高显著相关。
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