Department of Chemistry, College of Chemistry and Materials Engineering, Beijing Technology and Business University, Beijing, 100048, PR China.
School of Chemistry and Chemical Engineering, University of South China, Hengyang, 421001, PR China.
Biosens Bioelectron. 2025 Jan 1;267:116805. doi: 10.1016/j.bios.2024.116805. Epub 2024 Sep 20.
In recent years, aggregation-induced emission (AIE) materials have gained significant attention and have been developed for various applications in different fields including biomedical research, chemical analysis, optoelectronic devices, materials science, and nanotechnology. AIE is a unique luminescence phenomenon, and AIEgens are fluorescent moieties with relatively twisted structures that can overcome the aggregation-caused quenching (ACQ) effect. Additionally, AIEgens offer advantages such as non-washing properties, deep tissue penetration, minimal damage to biological structures, high signal-to-noise ratio, and excellent photostability. Fluorescent probes with AIE characteristics exhibit high sensitivity, short response time, simple operation, real-time detection capability, high selectivity, and excellent biocompatibility. As a result, they have been widely applied in cellular imaging, luminescent sensing, detection of physiological abnormalities in the human body, as well as early diagnosis and treatment of diseases. This review provides a comprehensive summary and discussion of the progress over the past four years regarding the detection of metal ions, small chemical molecules, biomacromolecules, microbes, and cells based on AIE materials, along with discussing their potential applications and future development prospects.
近年来，聚集诱导发光（AIE）材料受到了广泛关注，并在生物医学研究、化学分析、光电器件、材料科学和纳米技术等不同领域的各种应用中得到了发展。AIE 是一种独特的发光现象，AIE 分子是具有相对扭曲结构的荧光基团，可以克服聚集诱导猝灭（ACQ）效应。此外，AIE 分子还具有非洗涤性、深组织穿透性、对生物结构的最小损伤、高信噪比和优异的光稳定性等优点。具有 AIE 特性的荧光探针具有高灵敏度、短响应时间、操作简单、实时检测能力、高选择性和良好的生物相容性。因此，它们已广泛应用于细胞成像、发光传感、人体生理异常检测以及疾病的早期诊断和治疗。本综述全面总结和讨论了过去四年中基于 AIE 材料的金属离子、小分子、生物大分子、微生物和细胞检测方面的进展，并讨论了它们的潜在应用和未来发展前景。
