Faculty of Medicine, Universitas Padjadjaran, Bandung, Indonesia; Research Center for Care and Control of Infectious Diseases, Universitas Padjadjaran, Bandung, Indonesia.
Eijkman Institute for Molecular Biology, Jakarta, Indonesia; Division of Biological Anthropology, Department of Archaeology, University of Cambridge, Cambridge, UK.
Tuberculosis (Edinb). 2024 Dec;149:102568. doi: 10.1016/j.tube.2024.102568. Epub 2024 Sep 14.
Indonesia has the third highest number of tuberculosis (TB) patients infected with Mycobacterium tuberculosis (MTB) Lineage 1 (L1). Most of these MTB L1 cases can be found in Indonesia's remote easternmost province of Papua, one of Indonesia's most underdeveloped provinces with a particularly high burden for TB. In this study, we sequenced and described 42 MTB L1 isolates from a well-characterized cohort of patients. We found a genetically diverse MTB L1 population with no association between pathogen genetic relatedness and place of residence or pathogen genetic relatedness and patient ethnicity, which could reflect mixing between different locales and ethnicities or our low sampling fraction. Only a small number showed genetic variants associated with drug resistance (5/42, 11.9 %), probably due to a lack of effective treatment programs. The Papuan isolates showed similarities to other Island Southeast Asian Countries due to the high proportion of L1.2.1.2.1 (30/42, 71.4 %), especially East Timor and the Philippines. This study fills a research gap of MTB L1 in Indonesian Papua and should serve as a stepping stone for further research in the region.
印度尼西亚是感染结核分枝杆菌（MTB）谱系 1（L1）的肺结核（TB）患者数量第三多的国家。这些 MTB L1 病例大多出现在印度尼西亚最偏远的东部省份巴布亚，巴布亚是印度尼西亚最不发达的省份之一，结核病负担特别重。在这项研究中，我们对来自一个特征明确的患者队列的 42 株 MTB L1 分离株进行了测序和描述。我们发现了一个遗传多样性的 MTB L1 群体，病原体遗传相关性与居住地点或病原体遗传相关性与患者种族之间没有关联，这可能反映了不同地点和种族之间的混合，或者我们的抽样比例较低。只有少数显示与耐药性相关的遗传变异（5/42，11.9%），可能是由于缺乏有效的治疗方案。巴布亚分离株与其他东南亚岛国相似，因为 L1.2.1.2.1 的比例较高（30/42，71.4%），尤其是东帝汶和菲律宾。这项研究填补了印度尼西亚巴布亚地区 MTB L1 研究的空白，应该为该地区的进一步研究提供一个起点。
