Josephson A, Gombert M E, Sierra M F, Karanfil L V, Tansino G F
Infect Control. 1985 Sep;6(9):367-70. doi: 10.1017/s0195941700063335.
Medical patients receiving IV therapy were randomly assigned to one of two IV tubing change groups. One group had a 48-hour tubing change and the other had no tubing change for the remainder of the cannula placement. A daily IV fluid specimen was processed microbiologically. To complete the study, a minimum of 3 continuous days of therapy and three fluid specimens was required. There were two contaminated specimens, one in each tubing change group. The contamination rate in the 48-hour change group was 0.87% and 0.96% in the no change group. The rate difference of 0.09% has a 95% confidence interval (-0.035 to +0.036) which includes zero. Survival analysis also revealed no significant difference in the cumulative probability of survival, however the mean duration of continuous tubing use of 4.3 days in the no change group and 1.8 days in the 48 hour change group were significantly different (p less than 0.05). The cumulative probability of surviving contamination free was 0.988 in the 48-hour group and 0.987 in the no-change group. We conclude that it is safe to change IV tubing at intervals up to but not exceeding 4 days.
接受静脉输液治疗的医学患者被随机分配到两个静脉输液管更换组中的一组。一组每48小时更换一次输液管，另一组在留置套管的剩余时间内不更换输液管。每天采集的静脉输液样本进行微生物学处理。为完成该研究，至少需要连续3天的治疗和三个液体样本。有两个受污染的样本，每个输液管更换组各一个。48小时更换组的污染率为0.87%，未更换组为0.96%。0.09%的率差的95%置信区间为（-0.035至+0.036），其中包括零。生存分析还显示生存累积概率无显著差异，然而，未更换组连续使用输液管的平均持续时间为4.3天，48小时更换组为1.8天，两者存在显著差异（p小于0.05）。48小时组无污染物存活的累积概率为0.988，未更换组为0.987。我们得出结论，间隔不超过4天更换静脉输液管是安全的。
