Gorbea H F, Snydman D R, Delaney A, Stockman J, Martin W J
JAMA. 1984 Apr 27;251(16):2112-5.
No studies of safety in changing intravenous systems containing in-line burettes at 48 hours in an intensive care setting have been performed. Patients entering a surgical intensive care unit were alternatively assigned to have any line with an in-line burette changed at either 24-hour (64 patients) or 48-hour (59 patients) intervals. Daily quantitative cultures with a 2-mL aliquot of burette fluid were obtained. Contaminated burette fluid was detected in nine of 452 (2.0%; 95% confidence interval, 0.7% to 3.3%) samples from 24-hour interval burettes and in nine of 224 (4.0%; 95% confidence interval, 1.4% to 6.6%) samples from 48-hour interval burettes. Bacterial contamination of burette fluid with ten or more colonies per milliliter occurred in only five (1.1%) cultures from patients in the 24-hour interval group compared with only two cultures (0.9%) in the 48-hour group. None of the contaminated burette fluids was associated with primary bacteremia. Change of in-line burettes in intensive care at 48-hour intervals is safe and should result in substantial cost savings.
在重症监护环境下，尚未有关于在48小时更换含在线滴管的静脉输液系统安全性的研究。进入外科重症监护病房的患者被交替分配，将带有在线滴管的任何输液管分别按24小时（64例患者）或48小时（59例患者）的间隔进行更换。每天从滴管中取2 mL液体进行定量培养。在24小时间隔输液管的452个样本中有9个（2.0%；95%置信区间为0.7%至3.3%）检测到滴管液体被污染，在48小时间隔输液管的224个样本中有9个（4.0%；95%置信区间为1.4%至6.6%）检测到被污染。每毫升有十个或更多菌落的滴管液体细菌污染在24小时间隔组患者的培养物中仅出现5例（1.1%），而在48小时组中仅出现2例培养物（0.9%）。没有任何被污染的滴管液体与原发性菌血症相关。在重症监护中每48小时更换在线滴管是安全的，并且应该能大幅节省成本。
