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用于修复皮肤伤口和光老化损伤的重组胶原蛋白。

Recombinant collagen for the repair of skin wounds and photo-aging damage.

作者信息

Liu Taishan, Hao Jiayun, Lei Huan, Chen Yanru, Liu Lin, Jia Liping, Gu Juan, Kang Huaping, Shi Jingjing, He Jing, Song Yangbin, Tang Yuqi, Fan Daidi

机构信息

Shaanxi Key Laboratory of Degradable Biomedical Materials, School of Chemical Engineering, Northwest University, Xi'an 710069, China.

Shaanxi R&D Center of Biomaterials and Fermentation Engineering, School of Chemical Engineering, Northwest University, Xi'an 710069, China.

出版信息

Regen Biomater. 2024 Sep 2;11:rbae108. doi: 10.1093/rb/rbae108. eCollection 2024.

DOI:10.1093/rb/rbae108
PMID:39323745
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC11422187/
Abstract

The skin, being the body's primary defense mechanism, is susceptible to various injuries such as epidermal wounds, natural aging, and ultraviolet-induced damage. As a result, there is growing interest in researching skin repair methods. Traditional animal-derived collagen, widely available on the market, poses risks due to its immunogenicity and potential for viral contamination. In contrast, recombinant collagen sourced from human genes offers a safer alternative. To investigate the potential of human recombinant collagen in skin repair, our research team applied two types, type I human collagen (Col I) and CF-1552(I), to two different skin injury models: a wound-healing model and a photo-aging model. Our findings indicate that both Col I and CF-1552(I) effectively enhance wound healing and repair skin damaged by ultraviolet exposure. Notably, CF-1552(I) showed effects comparable to Col I in promoting cell proliferation in the wound-healing model and increasing malondialdehyde content in the photo-aging model, suggesting that CF-1552(I) may offer greater potential for skin repair compared to the larger Col I molecule.

摘要

皮肤作为人体的主要防御机制，易受到各种损伤，如表皮创伤、自然衰老和紫外线引起的损伤。因此，对皮肤修复方法的研究兴趣日益浓厚。市场上广泛存在的传统动物源胶原蛋白，因其免疫原性和病毒污染的可能性而存在风险。相比之下，源自人类基因的重组胶原蛋白提供了一种更安全的选择。为了研究人类重组胶原蛋白在皮肤修复中的潜力，我们的研究团队将两种类型的胶原蛋白，即I型人胶原蛋白（Col I）和CF - 1552(I)，应用于两种不同的皮肤损伤模型：伤口愈合模型和光老化模型。我们的研究结果表明，Col I和CF - 1552(I)均能有效促进伤口愈合，并修复紫外线照射损伤的皮肤。值得注意的是，在伤口愈合模型中，CF - 1552(I)在促进细胞增殖方面显示出与Col I相当的效果，在光老化模型中能增加丙二醛含量，这表明与更大的Col I分子相比，CF - 1552(I)在皮肤修复方面可能具有更大的潜力。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/ba4d/11422187/5458d0f83141/rbae108f7.jpg
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The influence of tag sequence on recombinant humanized collagen (rhCol) and the evaluation of rhCol on Schwann cell behaviors.
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