UF Health Jacksonville Department of Pharmacy, Jacksonville, Florida, USA.
UF College of Pharmacy, Jacksonville, Florida, USA.
Antimicrob Agents Chemother. 2024 Nov 6;68(11):e0075224. doi: 10.1128/aac.00752-24. Epub 2024 Sep 26.
Obesity affects over one-third of U.S. adults and complicates the treatment of methicillin-susceptible (MSSA) bloodstream infections (BSI). A study at the University of Florida Health Centers compared clinical outcomes between 233 obese and non-obese patients receiving cefazolin for MSSA BSI. No significant differences were found in clinical success (81.9% vs 82.7%), mortality (7.2% vs 5.3%), or adverse events (3.6% vs 3.3%). However, obese patients took longer to clear blood cultures (4.62 vs 4.01 days, = 0.017).
肥胖影响了超过三分之一的美国成年人，并使耐甲氧西林金黄色葡萄球菌（MSSA）血流感染（BSI）的治疗复杂化。佛罗里达大学健康中心的一项研究比较了 233 名肥胖和非肥胖患者接受头孢唑林治疗 MSSA BSI 的临床结果。在临床成功率（81.9%对 82.7%）、死亡率（7.2%对 5.3%）或不良事件（3.6%对 3.3%）方面均无显著差异。然而，肥胖患者清除血培养的时间更长（4.62 对 4.01 天，P=0.017）。
