Han Tuo, Li Ying, Xiao Jing, Gong Hong, Deng Fuxue, Jiang Wei, Wang Congxia, Chen Fangyao, Zhang Chunyan, Deng Jie, Zhang Yan
Department of Cardiology, The Second Affiliated Hospital of Xi'an Jiaotong University, Xi'an, 710004, People's Republic of China.
Department of Health Management, The Second Affiliated Hospital of Xi'an Jiaotong University, Xi'an, 710004, People's Republic of China.
Diabetes Metab Syndr Obes. 2024 Sep 21;17:3547-3556. doi: 10.2147/DMSO.S469398. eCollection 2024.
Approximately 10-20% of individuals with non-alcoholic fatty liver disease (NAFLD) are lean, and the underlying pathophysiology is not yet understood. This study aims to explore the characteristics and the diagnostic value of triglyceride-glucose index (TyG) in early diagnosis of lean NAFLD.
99 patients with lean NAFLD and 1891 healthy controls were included in the health examination. The characteristics were compared between groups. Restricted cubic spline was utilized to analyze the relationship between TyG index and the risk of lean NAFLD. Logistic regression and receiver operating curve (ROC) were applied to explore the diagnostic value of TyG index for lean NAFLD.
Overall, 99 (4.97%) patients had lean NAFLD. Patients with lean NAFLD have significant abnormal glycolipid metabolism and higher TyG index. Restriction cube spline analysis showed a significant dose-response relationship between the TyG index and risk of lean NAFLD. After adjusting for confounders, the relationship remained and the risk of developing lean NAFLD increased 2.99 times for per unit increase of TyG index (95% CI: 1.94, 4.67, <0.001). The areas under the ROC of the TyG index for lean NAFLD detection were 0.851 (0.815 to 0.886).
The TyG index is positively associated with the risk of developing lean NAFLD and could be a useful marker for early diagnosis of lean NAFLD.
大约10%-20%的非酒精性脂肪性肝病（NAFLD）患者体型消瘦，其潜在的病理生理学机制尚不清楚。本研究旨在探讨甘油三酯-葡萄糖指数（TyG）在消瘦型NAFLD早期诊断中的特征及诊断价值。
选取99例消瘦型NAFLD患者和1891例健康对照者进行健康体检。比较两组之间的特征。采用限制立方样条分析TyG指数与消瘦型NAFLD风险之间的关系。应用逻辑回归和受试者工作特征曲线（ROC）探讨TyG指数对消瘦型NAFLD的诊断价值。
总体而言，99例（4.97%）患者患有消瘦型NAFLD。消瘦型NAFLD患者存在明显的糖脂代谢异常且TyG指数较高。限制立方样条分析显示TyG指数与消瘦型NAFLD风险之间存在显著的剂量反应关系。在调整混杂因素后，这种关系仍然存在，TyG指数每增加一个单位，发生消瘦型NAFLD的风险增加2.99倍（95%CI：1.94，4.67，<0.001）。TyG指数检测消瘦型NAFLD的ROC曲线下面积为0.851（0.815至0.886）。
TyG指数与消瘦型NAFLD的发生风险呈正相关，可能是消瘦型NAFLD早期诊断的有用标志物。
