Operative Research Unit of Radiology and Interventional Radiology, Fondazione Policlinico Universitario Campus Bio-Medico di Roma, Via Alvaro del Portillo 200, 00128 Rome, Italy.
Research Unit of Radiology and Interventional Radiology, Department of Medicine and Surgery, Università Campus Bio-Medico di Roma, Via Alvaro del Portillo 21, 00128 Rome, Italy.
Curr Oncol. 2024 Sep 13;31(9):5422-5438. doi: 10.3390/curroncol31090401.
Interventional radiology techniques have become pivotal in recent years in managing metastatic bone disease, which frequently results in skeletal complications such as fractures and severe pain. Thermoablative methods like radiofrequency ablation (RFA) and microwave ablation (MWA), when combined with vertebroplasty (VP), are proving increasingly beneficial for these patients.
The search was independently conducted by two radiologists on MEDLINE databases, using specified strings up to April 2024. Methodological quality was assessed using PRISMA guidelines. Studies meeting inclusion criteria investigated thermoablation techniques (RFA and/or MWA) combined with VP, focusing on pain management and disease control outcomes in adults.
Among 147 results, 42 articles met the criteria, with varied prospective and retrospective designs and sample sizes averaging 49 patients, predominantly involving RFA (30 studies), MWA (11 studies), and one comparative study. Our review highlights significant pain reduction, effective local tumor control, and favorable safety of combined RFA or MWA with VP, supporting its potential in managing vertebral pathologies and warranting further clinical integration.
The combined treatment of RFA/MWA with VP demonstrates significant pain reduction and local tumor control, with a rapid onset of analgesic effect. These findings support its crucial role in clinical practice for managing vertebral metastases.
介入放射学技术近年来在治疗转移性骨病方面变得至关重要，转移性骨病常导致骨骼并发症，如骨折和严重疼痛。射频消融（RFA）和微波消融（MWA）等热消融方法与椎体成形术（VP）联合使用，对这些患者越来越有益。
两位放射科医生在 MEDLINE 数据库中独立进行了搜索，使用特定的字符串搜索至 2024 年 4 月。使用 PRISMA 指南评估方法学质量。符合纳入标准的研究调查了热消融技术（RFA 和/或 MWA）联合 VP 的应用，重点关注成年人的疼痛管理和疾病控制结果。
在 147 项研究结果中，有 42 篇文章符合标准，这些文章具有不同的前瞻性和回顾性设计，样本量平均为 49 例，主要涉及 RFA（30 项研究）、MWA（11 项研究）和一项比较研究。我们的综述强调了联合 RFA 或 MWA 与 VP 治疗可显著减轻疼痛、有效控制局部肿瘤，且具有良好的安全性，支持其在治疗脊柱病变方面的潜力，并需要进一步的临床整合。
RFA/MWA 联合 VP 的治疗可显著减轻疼痛和控制局部肿瘤，镇痛效果迅速出现。这些发现支持其在管理脊柱转移瘤的临床实践中发挥关键作用。
