Department of Endocrinology and Diabetology, University Medical Center Maribor, Ljubljanska Ulica 5, 2000 Maribor, Slovenia.
Faculty of Medicine, University of Maribor, Taborska Ulica 8, 2000 Maribor, Slovenia.
Curr Oncol. 2024 Sep 14;31(9):5452-5461. doi: 10.3390/curroncol31090403.
Insulinomas are rare functional neuroendocrine tumors that are usually indolent and small. Due to their rarity, there is often a delay in disease recognition and diagnosis, and small tumor size makes their localization challenging. Glucose monitoring and dietary modification with or without pharmacotherapy are crucial during diagnostics, and surgery is the only definite treatment. Continuous glucose monitoring (CGM) systems can be a valuable tool in managing insulinoma patients. We present three patients with confirmed endogenous hyperinsulinemic hypoglycemia undergoing tumor localization, medical treatment, and surgery while wearing a CGM system. By accurately depicting glucose fluctuations, CGM can help prevent hypoglycemia, decrease hypoglycemia unawareness, track hypoglycemia frequency, aid in medical therapy dose titration, and confirm a cure after surgery.
胰岛素瘤是罕见的功能性神经内分泌肿瘤，通常生长缓慢且体积较小。由于其罕见性，疾病的识别和诊断往往存在延迟，而且肿瘤体积小使得其定位具有挑战性。在诊断过程中，葡萄糖监测和饮食调整（包括药物治疗）至关重要，手术是唯一的明确治疗方法。连续血糖监测（CGM）系统是管理胰岛素瘤患者的有用工具。我们介绍了 3 例经证实的内源性高胰岛素血症性低血糖患者，他们在佩戴 CGM 系统的情况下进行肿瘤定位、药物治疗和手术。CGM 通过准确描绘血糖波动，可以帮助预防低血糖、减少低血糖意识丧失、跟踪低血糖发作频率、辅助药物治疗剂量调整，并在手术后确认治愈。
