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用于烧伤创面愈合的局部用益生菌水凝胶

Topical Probiotic Hydrogels for Burn Wound Healing.

作者信息

Arshad Tavinda, Mundrathi Varsha, Perez Victoria E, Nunez Jeilyn M, Cho Hyunah

机构信息

Industrial Pharmacy, Department of Pharmaceutical Sciences, College of Pharmacy and Health Sciences, St. John's University, Queens, NY 11439, USA.

出版信息

Gels. 2024 Aug 23;10(9):545. doi: 10.3390/gels10090545.

Abstract

Hydrogels have increasingly been used to enhance the effective healing of various wounds, including burn wounds. Similarly, the application of probiotics has recently been explored in wound healing and skin repairs. While probiotics have been consumed to provide therapeutic effects that aid with improving gut health, topical applications have been found to accelerate wound healing both in vitro and in vivo. For wounds that have complex healing mechanisms, such as burn wounds which depend on factors such as the depth of the burn, size of the afflicted area, and cause of the injury, probiotics with or without conventional therapeutic agents topically delivered via hydrogel technology are proven to be effective in the recovery of the damaged skin. This article aims to investigate the microorganisms present in the human skin microbiome and observe the effects of probiotics delivered by hydrogels on burn wound healing.

摘要

水凝胶已越来越多地用于促进包括烧伤创面在内的各种伤口的有效愈合。同样,益生菌在伤口愈合和皮肤修复方面的应用最近也得到了探索。虽然食用益生菌可提供有助于改善肠道健康的治疗效果,但已发现局部应用益生菌能在体外和体内加速伤口愈合。对于具有复杂愈合机制的伤口,如取决于烧伤深度、患区大小和损伤原因等因素的烧伤创面,通过水凝胶技术局部递送的含有或不含有传统治疗剂的益生菌已被证明对受损皮肤的恢复有效。本文旨在研究人类皮肤微生物群中存在的微生物,并观察水凝胶递送的益生菌对烧伤创面愈合的影响。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/170c/11431453/701029d248c1/gels-10-00545-g001.jpg

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